| 词条 | Prazitone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 449584977 | IUPAC_name = 5-phenyl-5-(piperidin-2-ylmethyl)pyrimidine-2,4,6(1H,3H,5H)-trione | image = Prazitone.png | width = 200 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 2409-26-9 | ATC_prefix = none | ATC_suffix = | PubChem = 3050417 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 6DZB018428 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 2312482 | C = 16 | H = 19 | N = 3 | O = 3 | molecular_weight = 301.34 g/mol | synonyms = 5-phenyl-5-(2-piperidylmethyl)barbituric acid | smiles = C1CCNC(C1)CC2(C(=O)NC(=O)NC2=O)C3=CC=CC=C3 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C16H19N3O3/c20-13-16(11-6-2-1-3-7-11,14(21)19-15(22)18-13)10-12-8-4-5-9-17-12/h1-3,6-7,12,17H,4-5,8-10H2,(H2,18,19,20,21,22) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = UGZAKKMLMJITLL-UHFFFAOYSA-N }} Prazitone (AGN-511) is a barbiturate derivative developed in the 1970s.[1] Unlike most barbiturates, it has little or no sedative effects, instead acting as a non-sedating anxiolytic and antidepressant.[2] The dosage range in humans is around 200–600 mg, although higher doses have been used in trials for the treatment of depression associated with Parkinson's disease. References1. ^DE Patent 1645911 {{Antidepressants}}{{Anxiolytics}}{{Piperazines}}{{nervous-system-drug-stub}}2. ^Ross Langlands. Method for imparting anti-depressant and/or anxiolytic effects to animals. US Patent 3,806,596 5 : Antidepressants|Anxiolytics|Barbiturates|Piperidines|Pyrimidines |
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