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词条 PRKAA2
释义

  1. Function

  2. References

  3. Further reading

{{Infobox_gene}}5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.[1][2]

Function

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.[2]

References

1. ^{{cite journal | vauthors = Aguan K, Scott J, See CG, Sarkar NH | title = Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals | journal = Gene | volume = 149 | issue = 2 | pages = 345–50 | date = Dec 1994 | pmid = 7959015 | pmc = | doi = 10.1016/0378-1119(94)90174-0 }}
2. ^1 {{cite web | title = Entrez Gene: PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5563| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Hardie DG, MacKintosh RW | title = AMP-activated protein kinase--an archetypal protein kinase cascade? | journal = BioEssays | volume = 14 | issue = 10 | pages = 699–704 | year = 1995 | pmid = 1365882 | doi = 10.1002/bies.950141011 }}
  • {{cite journal | vauthors = Hardie DG | title = Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase | journal = Biochim. Biophys. Acta | volume = 1123 | issue = 3 | pages = 231–8 | year = 1992 | pmid = 1536860 | doi = 10.1016/0005-2760(92)90001-c }}
  • {{cite journal | vauthors = Carling D | title = The AMP-activated protein kinase cascade--a unifying system for energy control | journal = Trends Biochem. Sci. | volume = 29 | issue = 1 | pages = 18–24 | year = 2004 | pmid = 14729328 | doi = 10.1016/j.tibs.2003.11.005 }}
  • {{cite journal | vauthors = Beri RK, Marley AE, See CG, Sopwith WF, Aguan K, Carling D, Scott J, Carey F | title = Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase | journal = FEBS Lett. | volume = 356 | issue = 1 | pages = 117–21 | year = 1995 | pmid = 7988703 | doi = 10.1016/0014-5793(94)01247-4 }}
  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
  • {{cite journal | vauthors = Vavvas D, Apazidis A, Saha AK, Gamble J, Patel A, Kemp BE, Witters LA, Ruderman NB | title = Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle | journal = J. Biol. Chem. | volume = 272 | issue = 20 | pages = 13255–61 | year = 1997 | pmid = 9148944 | doi = 10.1074/jbc.272.20.13255 }}
  • {{cite journal | vauthors = Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE | title = AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location | journal = FEBS Lett. | volume = 409 | issue = 3 | pages = 452–6 | year = 1997 | pmid = 9224708 | doi = 10.1016/S0014-5793(97)00569-3 }}
  • {{cite journal | vauthors = Stein SC, Woods A, Jones NA, Davison MD, Carling D | title = The regulation of AMP-activated protein kinase by phosphorylation | journal = Biochem. J. | volume = 345 | issue = 3 | pages = 437–43 | year = 2000 | pmid = 10642499 | pmc = 1220775 | doi = 10.1042/0264-6021:3450437 }}
  • {{cite journal | vauthors = da Silva Xavier G, Leclerc I, Salt IP, Doiron B, Hardie DG, Kahn A, Rutter GA | title = Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 8 | pages = 4023–8 | year = 2000 | pmid = 10760274 | pmc = 18135 | doi = 10.1073/pnas.97.8.4023 }}
  • {{cite journal | vauthors = Mu J, Brozinick JT, Valladares O, Bucan M, Birnbaum MJ | title = A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle | journal = Mol. Cell | volume = 7 | issue = 5 | pages = 1085–94 | year = 2001 | pmid = 11389854 | doi = 10.1016/S1097-2765(01)00251-9 }}
  • {{cite journal | vauthors = Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Müller C, Carling D, Kahn BB | title = Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase | journal = Nature | volume = 415 | issue = 6869 | pages = 339–43 | year = 2002 | pmid = 11797013 | doi = 10.1038/415339a }}
  • {{cite journal | vauthors = Dubbelhuis PF, Meijer AJ | title = Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase | journal = FEBS Lett. | volume = 521 | issue = 1–3 | pages = 39–42 | year = 2002 | pmid = 12067722 | doi = 10.1016/S0014-5793(02)02815-6 }}
  • {{cite journal | vauthors = Esumi H, Izuishi K, Kato K, Hashimoto K, Kurashima Y, Kishimoto A, Ogura T, Ozawa T | title = Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner | journal = J. Biol. Chem. | volume = 277 | issue = 36 | pages = 32791–8 | year = 2002 | pmid = 12091379 | doi = 10.1074/jbc.M112270200 }}
  • {{cite journal | vauthors = Nielsen JN, Mustard KJ, Graham DA, Yu H, MacDonald CS, Pilegaard H, Goodyear LJ, Hardie DG, Richter EA, Wojtaszewski JF | title = 5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle | journal = J. Appl. Physiol. | volume = 94 | issue = 2 | pages = 631–41 | year = 2003 | pmid = 12391032 | doi = 10.1152/japplphysiol.00642.2002 }}
  • {{cite journal | vauthors = Wojtaszewski JF, Mourtzakis M, Hillig T, Saltin B, Pilegaard H | title = Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise | journal = Biochem. Biophys. Res. Commun. | volume = 298 | issue = 3 | pages = 309–16 | year = 2002 | pmid = 12413941 | doi = 10.1016/S0006-291X(02)02465-8 }}
  • {{cite journal | vauthors = Hallows KR, McCane JE, Kemp BE, Witters LA, Foskett JK | title = Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells | journal = J. Biol. Chem. | volume = 278 | issue = 2 | pages = 998–1004 | year = 2003 | pmid = 12427743 | doi = 10.1074/jbc.M210621200 }}
  • {{cite journal | vauthors = Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI | title = AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 25 | pages = 15983–7 | year = 2003 | pmid = 12444247 | pmc = 138551 | doi = 10.1073/pnas.252625599 }}
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1 : EC 2.7.11
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