“PRKCI”的意思、由来-开放百科全书

Function

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.^[3]

References

1. ^{{cite journal | vauthors = Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D'Urso M, D'Esposito M | title = Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3 | journal = Genomics | volume = 26 | issue = 3 | pages = 629–31 | date = Apr 1995 | pmid = 7607695 | pmc = | doi = 10.1016/0888-7543(95)80190-W }}
2. ^{{cite journal | vauthors = De Donato M, Gallagher DS, Davis SK, Stelly DM, Taylor JF | title = The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3 | journal = Cytogenetics and Cell Genetics | volume = 95 | issue = 1–2 | pages = 79–81 | date = April 2002 | pmid = 11978974 | pmc = | doi = 10.1159/000057021 }}
3. ^¹{{cite web | title = Entrez Gene: PRKCI protein kinase C, iota| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5584| accessdate = }}
4. ^{{cite journal | vauthors = Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A | title = Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C | journal = Biochemical and Biophysical Research Communications | volume = 307 | issue = 3 | pages = 459–65 | date = Aug 2003 | pmid = 12893243 | doi = 10.1016/s0006-291x(03)01187-2}}
5. ^{{cite journal | vauthors = Lim YP, Low BC, Lim J, Wong ES, Guy GR | title = Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19025–34 | date = Jul 1999 | pmid = 10383403 | doi = 10.1074/jbc.274.27.19025}}
6. ^{{cite journal | vauthors = Tisdale EJ | title = Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3334–41 | date = Feb 2002 | pmid = 11724794 | doi = 10.1074/jbc.M109744200 }}
7. ^{{cite journal | vauthors = Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT | title = Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62 | journal = Molecular and Cellular Biology | volume = 18 | issue = 5 | pages = 3069–80 | date = May 1998 | pmid = 9566925 | pmc = 110686 | doi = 10.1128/mcb.18.5.3069}}
8. ^{{cite journal | vauthors = Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H | title = PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions | journal = Biochemical and Biophysical Research Communications | volume = 299 | issue = 4 | pages = 641–6 | date = Dec 2002 | pmid = 12459187 | doi = 10.1016/s0006-291x(02)02698-0}}
9. ^{{cite journal | vauthors = Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR | title = A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 27 | pages = 20806–13 | date = Jul 2000 | pmid = 10764742 | doi = 10.1074/jbc.M000421200 }}
10. ^{{cite journal | vauthors = Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J | title = Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo | journal = Molecular and Cellular Biology | volume = 16 | issue = 1 | pages = 105–14 | date = Jan 1996 | pmid = 8524286 | pmc = 230983 | doi = }}
11. ^{{cite journal | vauthors = Guo W, Wu S, Liu J, Fang B | title = Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. | journal = Cancer Research | volume = 68 | issue = 18 | pages = 7403–8 | date = Sep 2008 | pmid = 18794128 | doi = 10.1158/0008-5472.CAN-08-1449 | pmc=2678915}}
12. ^{{cite journal |vauthors=Ratnayake WS, Apostolatos AH, Ostrov DA, Acevedo-Duncan M | title = Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis | journal = Int. J. Oncol. | volume = 51 | issue = 5 | pages = 1370-1382 | year = 2017 | pmid = 29048609 | doi = 10.3892/ijo.2017.4131 | pmc=5642393}}
13. ^{{cite journal |vauthors=Ratnayake WS, Apostolatos CA, Apostolatos AH, Schutte RJ, Huynh MA, Ostrov DA, Acevedo-Duncan M | title = Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors | journal = Cell Adhes. Migr.| volume = 0 | issue = 0 | pages = 1-17 | year = 2018 | pmid = 29781749 | doi = 10.1080/19336918.2018.1471323}}

Further reading

{{cite journal | vauthors = Suzuki A, Akimoto K, Ohno S | title = Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms | journal = Journal of Biochemistry | volume = 133 | issue = 1 | pages = 9–16 | date = Jan 2003 | pmid = 12761193 | doi = 10.1093/jb/mvg018 }}

{{cite journal | vauthors = Fields AP, Regala RP | title = Protein kinase C iota: human oncogene, prognostic marker and therapeutic target | journal = Pharmacological Research | volume = 55 | issue = 6 | pages = 487–97 | date = Jun 2007 | pmid = 17570678 | pmc = 2705893 | doi = 10.1016/j.phrs.2007.04.015 }}

{{cite journal | vauthors = Ruegg CL, Strand M | title = A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx | journal = Cellular Immunology | volume = 137 | issue = 1 | pages = 1–13 | date = Oct 1991 | pmid = 1832084 | doi = 10.1016/0008-8749(91)90051-C }}

{{cite journal | vauthors = Chowdhury IH, Koyanagi Y, Kobayashi S, Hamamoto Y, Yoshiyama H, Yoshida T, Yamamoto N | title = The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway | journal = Virology | volume = 176 | issue = 1 | pages = 126–32 | date = May 1990 | pmid = 1970444 | doi = 10.1016/0042-6822(90)90237-L }}

{{cite journal | vauthors = Ruegg CL, Strand M | title = Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41 | journal = Journal of Immunology | volume = 144 | issue = 10 | pages = 3928–35 | date = May 1990 | pmid = 2139676 | url = http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=2139676 }}

{{cite journal | vauthors = Jakobovits A, Rosenthal A, Capon DJ | title = Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C | journal = The EMBO Journal | volume = 9 | issue = 4 | pages = 1165–70 | date = Apr 1990 | pmid = 2182321 | pmc = 551792 }}

{{cite journal | vauthors = Fields AP, Bednarik DP, Hess A, May WS | title = Human immunodeficiency virus induces phosphorylation of its cell surface receptor | journal = Nature | volume = 333 | issue = 6170 | pages = 278–80 | date = May 1988 | pmid = 3259291 | doi = 10.1038/333278a0 }}

{{cite journal | vauthors = Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S | title = HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells | journal = The Journal of Biological Chemistry | volume = 270 | issue = 33 | pages = 19364–9 | date = Aug 1995 | pmid = 7642615 | doi = 10.1074/jbc.270.33.19364 }}

{{cite journal | vauthors = Ward NE, Gravitt KR, O'Brian CA | title = Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein | journal = Cancer Letters | volume = 88 | issue = 1 | pages = 37–40 | date = Jan 1995 | pmid = 7850771 | doi = 10.1016/0304-3835(94)03610-U }}

{{cite journal | vauthors = Gupta S, Aggarwal S, Kim C, Gollapudi S | title = Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report | journal = International Journal of Immunopharmacology | volume = 16 | issue = 3 | pages = 197–204 | date = Mar 1994 | pmid = 8206685 | doi = 10.1016/0192-0561(94)90013-2 }}

{{cite journal | vauthors = Selbie LA, Schmitz-Peiffer C, Sheng Y, Biden TJ | title = Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells | journal = The Journal of Biological Chemistry | volume = 268 | issue = 32 | pages = 24296–302 | date = Nov 1993 | pmid = 8226978 }}

{{cite journal | vauthors = Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J | title = Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo | journal = Molecular and Cellular Biology | volume = 16 | issue = 1 | pages = 105–14 | date = Jan 1996 | pmid = 8524286 | pmc = 230983 | url = http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=8524286 }}

{{cite journal | vauthors = Parada NA, Cruikshank WW, Danis HL, Ryan TC, Center DM | title = IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C | journal = Cellular Immunology | volume = 168 | issue = 1 | pages = 100–6 | date = Feb 1996 | pmid = 8599832 | doi = 10.1006/cimm.1996.0054 }}

{{cite journal | vauthors = Conant K, Ma M, Nath A, Major EO | title = Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes | journal = Journal of Virology | volume = 70 | issue = 3 | pages = 1384–9 | date = Mar 1996 | pmid = 8627654 | pmc = 189957 | url = http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=8627654 }}

{{cite journal | vauthors = Díaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J | title = The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C | journal = Cell | volume = 86 | issue = 5 | pages = 777–86 | date = Sep 1996 | pmid = 8797824 | doi = 10.1016/S0092-8674(00)80152-X }}

{{cite journal | vauthors = Holmes AM | title = In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46 | journal = Archives of Biochemistry and Biophysics | volume = 335 | issue = 1 | pages = 8–12 | date = Nov 1996 | pmid = 8914829 | doi = 10.1006/abbi.1996.0476 }}

{{cite journal | vauthors = Murray NR, Fields AP | title = Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 27521–4 | date = Oct 1997 | pmid = 9346882 | doi = 10.1074/jbc.272.44.27521 }}

{{cite journal | vauthors = Borgatti P, Zauli G, Cantley LC, Capitani S | title = Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells | journal = Biochemical and Biophysical Research Communications | volume = 242 | issue = 2 | pages = 332–7 | date = Jan 1998 | pmid = 9446795 | doi = 10.1006/bbrc.1997.7877 }}

{{cite journal | vauthors = Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT | title = Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62 | journal = Molecular and Cellular Biology | volume = 18 | issue = 5 | pages = 3069–80 | date = May 1998 | pmid = 9566925 | pmc = 110686 | url = http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=9566925 | doi=10.1128/mcb.18.5.3069}}

1 : EC 2.7.11

Function

Interactions

References

Further reading