| 词条 | Promestriene |
| 释义 |
| Verifiedfields = verified | Watchedfields = verified | verifiedrevid = 444415121 | IUPAC_name = (8R,9S,13S,14S)-17-methoxy-13-methyl-3-propoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene | image = Promestriene skeletal.svg | width = 250px | tradename = Colpotrofin, Colpotrophine, Delipoderm | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Topical | class = Estrogen; Estrogen ester | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 39219-28-8 | CAS_supplemental = | ATC_prefix = G03 | ATC_suffix = CA09 | PubChem = 71717 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 64767 | synonyms = Estradiol 3-propyl 17β-methyl diether; 17β-Methoxy-3-propoxyestra-1,3,5(10)-triene | C=22 | H=32 | O=2 | molecular_weight = 328.488 g/mol | SMILES = CCCOc1ccc2c(c1)CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4OC)C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C22H32O2/c1-4-13-24-16-6-8-17-15(14-16)5-7-19-18(17)11-12-22(2)20(19)9-10-21(22)23-3/h6,8,14,18-21H,4-5,7,9-13H2,1-3H3/t18-,19-,20+,21?,22+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = IUWKNLFTJBHTSD-QIKJAYGVSA-N }}Promestriene ({{abbrlink|INN|International Nonproprietary Name}}) (brand names Colpotrofin, Colpotrophine, Delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic steroidal estrogen which is used topically in a 1% cream formulation.[1][2][3][4] It is the 3-propyl and 17β-methyl diether of estradiol.[5] The drug is described as a tropic agent and antiseborrheic.[1] It has not been found to be effective in the treatment of androgenic alopecia or other conditions of cutaneous androgenization.[6][7] See also
References1. ^1 {{cite book|author1=C.R. Ganellin|author2=David J. Triggle|title=Dictionary of Pharmacological Agents|url=https://books.google.com/books?id=A0THacd46ZsC&pg=PA1671|date=21 November 1996|publisher=CRC Press|isbn=978-0-412-46630-4|pages=1671–}} {{Estrogens and antiestrogens}}{{Estrogen receptor modulators}}{{Steroid-stub}}{{Genito-urinary-drug-stub}}2. ^{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1561|date=January 2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=1248, 1266, 1318, 1557}} 3. ^{{cite book|author=William Andrew Publishing|title=Pharmaceutical Manufacturing Encyclopedia, 3rd Edition|url=https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA2935-IA449|date=22 October 2013|publisher=Elsevier|isbn=978-0-8155-1856-3|pages=270–271}} 4. ^{{cite book|author=Muller|title=European Drug Index: European Drug Registrations, Fourth Edition|url=https://books.google.com/books?id=HiSdvzs2pPAC&pg=PA332|date=19 June 1998|publisher=CRC Press|isbn=978-3-7692-2114-5|pages=289, 332}} 5. ^{{cite journal |vauthors=Santos I, Clissold S |title=Urogenital disorders associated with oestrogen deficiency: the role of promestriene as topical oestrogen therapy |journal=Gynecol. Endocrinol. |volume=26 |issue=9 |pages=644–51 |year=2010 |pmid=20374067 |doi=10.3109/09513591003767948 |url=}} 6. ^{{cite book|author1=C.E. Orfanos|author2=W. Montagna|author3=G. Stüttgen|title=Hair Research: Status and Future Aspects; Proceedings of the First International Congress on Hair Research, Hamburg, March 13th–16, 1979|url=https://books.google.com/books?id=4gBJCAAAQBAJ&pg=PT553|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-81650-5|pages=553–}} 7. ^{{cite book|author1=Robert Baran|author2=Howard I. Maibach|title=Textbook of Cosmetic Dermatology|url=https://books.google.com/books?id=yIVfq5Lpl2EC&pg=PA493|date=1 October 1998|publisher=CRC Press|isbn=978-1-85317-478-0|pages=493–}} 4 : Diols|Estranes|Estrogen ethers|Synthetic estrogens |
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