“Propanoyl-CoA C-acyltransferase”的意思、由来-开放百科全书

词条

Propanoyl-CoA C-acyltransferase

释义

References

{{enzyme
| Name = Propanoyl-CoA C-acyltransferase
| EC_number = 2.3.1.176
| CAS_number =
| IUBMB_EC_number = 2/3/1/176
| GO_code =
| image =
| width =
| caption =
}}

In enzymology, a propanoyl-CoA C-acyltransferase ({{EC number|2.3.1.176}}) is an enzyme that catalyzes the chemical reaction

3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA

Thus, the two substrates of this enzyme are 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA and propanoyl-CoA, whereas its two products are CoA and 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase. Other names in common use include peroxisomal thiolase 2, sterol carrier protein-, SCP, and PTE-2 (ambiguous). This enzyme participates in ppar signaling pathway.

Propanoyl-CoA C-acyltransferase belongs to the thiolase family of enzymes.

References

{{cite journal | vauthors = Pedersen JI, Gustafsson J | date = 1980 | title = Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes | journal = FEBS Lett. | volume = 121 | pages = 345–8 | pmid = 7461136 | issue = 2 | doi=10.1016/0014-5793(80)80377-2 }}
{{cite journal | vauthors = Kase F, Bjorkhem I, Pedersen JI | date = 1983 | title = Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes | journal = J. Lipid Res. | volume = 24 | pages = 1560–7 | pmid = 6668450 | issue = 12 }}
{{cite journal | author = Russell DW | date = 2003 | title = The enzymes, regulation, and genetics of bile acid synthesis | journal = Annu. Rev. Biochem. | volume = 72 | pages = 137–74 | pmid = 12543708 | doi = 10.1146/annurev.biochem.72.121801.161712 }}
{{cite journal | vauthors = Falany CN, Johnson MR, Barnes S, Diasio RB | date = 1994 | title = Glycine and taurine conjugation of bile acids by a single enzyme Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase | journal = J. Biol. Chem. | volume = 269 | pages = 19375–9 | pmid = 8034703 | issue = 30 }}

2 : EC 2.3.1|Enzymes of unknown structure

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