| 释义 |
- References
- Further reading
- External links
{{Underlinked|date=June 2016}}{{Infobox_gene}}Thymus-specific serine protease is an enzyme that in humans is encoded by the PRSS16 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.[2]
}}References1. ^{{cite journal | vauthors = Bowlus CL, Ahn J, Chu T, Gruen JR | title = Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus | journal = Cell Immunol | volume = 196 | issue = 2 | pages = 80–6 |date=Nov 1999 | pmid = 10527559 | pmc = | doi = 10.1006/cimm.1999.1543 }}
2. ^1 {{cite web | title = Entrez Gene: PRSS16 protease, serine, 16 (thymus)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10279| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Lie BA, Viken MK, Akselsen HE, etal |title=Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease |journal=Hum. Immunol. |volume=68 |issue= 7 |pages= 592–8 |year= 2007 |pmid= 17584581 |doi= 10.1016/j.humimm.2007.03.009 }}
- {{cite journal |vauthors=Luther C, Wienhold W, Oehlmann R, etal |title=Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus |journal=Genes Immun. |volume=6 |issue= 1 |pages= 1–7 |year= 2005 |pmid= 15592422 |doi= 10.1038/sj.gene.6364142 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
- {{cite journal |vauthors=Lie BA, Akselsen HE, Bowlus CL, etal |title=Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases |journal=Genes Immun. |volume=3 |issue= 5 |pages= 306–12 |year= 2003 |pmid= 12140752 |doi= 10.1038/sj.gene.6363858 }}
- {{cite journal |vauthors=Gruen JR, Nalabolu SR, Chu TW, etal |title=A transcription map of the major histocompatibility complex (MHC) class I region |journal=Genomics |volume=36 |issue= 1 |pages= 70–85 |year= 1997 |pmid= 8812418 |doi=10.1006/geno.1996.0427 }}
{{refend}}External links- {{UCSC genome browser|PRSS16}}
- {{UCSC gene details|PRSS16}}
{{gene-6-stub}} |