| 词条 | Psychotridine |
| 释义 |
| IUPAC_name = 3-methyl-5,8b-bis[3-methyl-5-(3-methyl-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-8b-yl)-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-8b-yl]-1,2,3a,4-tetrahydropyrrolo[2,3-b]indole | image = Psychotridine.png | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 52617-25-1 | ATC_prefix = none | ATC_suffix = | PubChem = 171175 | ChemSpiderID = 149650 | C=55 | H=62 | N=10 | molecular_weight = 863.15 g/mol | SMILES = CN1CCC2(C1NC1=CC=CC=C21)C1=CC=CC2=C1NC1N(C)CCC21C1=CC=CC2=C1NC1N(C)CCC21C12CCN(C)C1NC1=C2C=CC=C1C12CCN(C)C1NC1=CC=CC=C21 }}Psychotridine is an alkaloid found in some species of the genus Psychotria, namely Psychotria colorata,[1] but also Psychotria forsteriana,[2] Psychotria lyciiflora,[3] Psychotria oleoides,[3] and Psychotria beccarioides.[4] Psychotridine has analgesic effects and dose-dependently inhibits dizocilpine binding to cortical membranes in vitro, suggesting that it acts as a non-competitive NMDA receptor antagonist.[1] See also
References1. ^1 {{cite journal |vauthors=Amador TA, Verotta L, Nunes DS, Elisabetsky E | title = Involvement of NMDA receptors in the analgesic properties of psychotridine | journal = Phytomedicine | volume = 8 | issue = 3 | pages = 202–6 |date=May 2001 | pmid = 11417913 | doi = 10.1078/0944-7113-00025| url = }} {{Analgesics}}{{Ionotropic glutamate receptor modulators}}{{analgesic-stub}}2. ^{{cite journal |vauthors=Beretz A, Roth-Georger A, Corre G, Kuballa B, Anton R, Cazenave JP | title = Polyindolinic Alkaloids from Psychotria forsteriana. Potent Inhibitors of the Aggregation of Human Platelets | journal = Planta Medica | volume = 51 | issue = 4 | pages = 300–3 |date=August 1985 | pmid = 17340518 | doi = 10.1055/s-2007-969496 | url = http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-969496}} 3. ^1 {{cite journal |vauthors=Jannic V, Guéritte F, Laprévote O, etal | title = Pyrrolidinoindoline alkaloids from Psychotria oleoides and Psychotria lyciiflora | journal = Journal of Natural Products | volume = 62 | issue = 6 | pages = 838–43 |date=June 1999 | pmid = 10395499 | doi = 10.1021/np9805387 }} 4. ^{{cite journal | title = Psychotridine, a C55H62N10 alkaloid from Psychotria beccarioides (Rubiaceae) | journal = Australian Journal of Chemistry | year = 1974 | volume = 27 | issue = 3 | pages = 639–646 | doi=10.1071/ch9740639}} 3 : Alkaloids|NMDA receptor antagonists|Pyrroloindoles |
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