| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.[1][2] Function The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. PTPs are known to be signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.[2] Interactions PTPN14 has been shown to interact with Beta-catenin.[3] References 1. ^{{cite journal | vauthors = Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR | title = Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains | journal = Biochemical and Biophysical Research Communications | volume = 209 | issue = 3 | pages = 959–65 | date = Apr 1995 | pmid = 7733990 | pmc = | doi = 10.1006/bbrc.1995.1591 }}
2. ^1 {{cite web | title = Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5784| accessdate = }}
3. ^{{cite journal | vauthors = Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y | title = The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin | journal = Molecular Biology of the Cell | volume = 14 | issue = 6 | pages = 2520–9 | date = Jun 2003 | pmid = 12808048 | pmc = 194899 | doi = 10.1091/mbc.E02-09-0577 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J | title = The 1993-94 Généthon human genetic linkage map | journal = Nature Genetics | volume = 7 | issue = 2 Spec No | pages = 246–339 | date = Jun 1994 | pmid = 7545953 | doi = 10.1038/ng0694supp-246 }}
- {{cite journal | vauthors = Ogata M, Takada T, Mori Y, Oh-hora M, Uchida Y, Kosugi A, Miyake K, Hamaoka T | title = Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 18 | pages = 12905–9 | date = Apr 1999 | pmid = 10212280 | doi = 10.1074/jbc.274.18.12905 }}
- {{cite journal | vauthors = Ogata M, Takada T, Mori Y, Uchida Y, Miki T, Okuyama A, Kosugi A, Sawada M, Oh-hora M, Hamaoka T | title = Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion | journal = The Journal of Biological Chemistry | volume = 274 | issue = 29 | pages = 20717–24 | date = Jul 1999 | pmid = 10400706 | doi = 10.1074/jbc.274.29.20717 }}
- {{cite journal | vauthors = Aoyama K, Matsuda T, Aoki N | title = Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36 | journal = Biochemical and Biophysical Research Communications | volume = 266 | issue = 2 | pages = 523–31 | date = Dec 1999 | pmid = 10600535 | doi = 10.1006/bbrc.1999.1845 }}
- {{cite journal | vauthors = Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y | title = Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation | journal = Journal of Cell Science | volume = 113 ( Pt 17) | issue = 17 | pages = 3117–23 | date = Sep 2000 | pmid = 10934049 | doi = }}
- {{cite journal | vauthors = Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y | title = The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin | journal = Molecular Biology of the Cell | volume = 14 | issue = 6 | pages = 2520–9 | date = Jun 2003 | pmid = 12808048 | pmc = 194899 | doi = 10.1091/mbc.E02-09-0577 }}
- {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
- {{cite journal | vauthors = Barr AJ, Debreczeni JE, Eswaran J, Knapp S | title = Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution | journal = Proteins | volume = 63 | issue = 4 | pages = 1132–6 | date = Jun 2006 | pmid = 16534812 | doi = 10.1002/prot.20958 }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
{{refend}}{{PDB Gallery|geneid=5784}}{{Protein tyrosine phosphatases}}{{gene-1-stub}} |