| 词条 | PYLIS downstream sequence |
| 释义 |
| Name = Pyrrolysine insertion sequence 1 | image = PHYLIS SS.png | width = | caption = Predicted secondary structure of PYLIS 1 RNA. | Symbol = PYLIS 1 | AltSymbols = | Rfam = RF01982 | miRBase = | miRBase_family = | RNA_type = Cis-regulatory element | Tax_domain = Archaea | GO = | SO = | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} In biology, the PYLIS downstream sequence (PYLIS: pyrrolysine insertion sequence) is a stem-loop structure that appears on some mRNA sequences. This structural motif was previously thought to cause the UAG (amber) stop codon to be translated to the amino acid pyrrolysine instead of ending the protein translation.[1][2][3] However, it has been shown that PYLIS has no effect upon the efficiency of the UAG suppression,[4] hence even its name is, in fact, incorrect. See also
References1. ^{{cite journal |vauthors=Namy O, Rousset JP, Napthine S, Brierley I |title=Reprogrammed genetic decoding in cellular gene expression |journal=Molecular Cell |volume=13 |issue=2 |pages=157–68 |year=2004 |pmid=14759362 |doi=10.1016/S1097-2765(04)00031-0 |url=}} 2. ^{{cite journal |vauthors=Théobald-Dietrich A, Giegé R, Rudinger-Thirion J |title=Evidence for the existence in mRNAs of a hairpin element responsible for ribosome dependent pyrrolysine insertion into proteins |journal=Biochimie |volume=87 |issue=9–10 |pages=813–7 |year=2005 |pmid=16164991 |doi=10.1016/j.biochi.2005.03.006 |url=}} 3. ^{{cite journal |vauthors=Zhang Y, Baranov PV, Atkins JF, Gladyshev VN |title=Pyrrolysine and selenocysteine use dissimilar decoding strategies |journal=J. Biol. Chem. |volume=280 |issue=21 |pages=20740–51 |date=May 2005 |pmid=15788401 |doi=10.1074/jbc.M501458200 |url=}} 4. ^{{cite journal|last1=Namy|first1=Olivier|last2=Zhou|first2=Yu|last3=Gundllapalli|first3=Sarath|last4=Polycarpo|first4=Carla R.|last5=Denise|first5=Alain|last6=Rousset|first6=Jean-Pierre|last7=Söll|first7=Dieter|last8=Ambrogelly|first8=Alexandre|title=Adding pyrrolysine to the Escherichia coli genetic code|journal=FEBS Letters|date=November 2007|volume=581|issue=27|pages=5282–8|pmid=17967457|doi=10.1016/j.febslet.2007.10.022|url=http://www.sciencedirect.com/science/article/pii/S0014579307010824|accessdate=18 October 2015}} Further reading
External links
1 : Cis-regulatory RNA elements |
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