“Pyridoxal phosphatase”的意思、由来-开放百科全书

词条

Pyridoxal phosphatase

释义

Structural studies
References

{{enzyme
| Name = Pyridoxal phosphatase
| EC_number = 3.1.3.74
| CAS_number =
| IUBMB_EC_number = 3/1/3/74
| GO_code =
| image =
| width =
| caption =
}}

In enzymology, a pyridoxal phosphatase ({{EC number|3.1.3.74}}) is an enzyme that catalyzes the chemical reaction

pyridoxal 5'-phosphate + H₂O pyridoxal + phosphate

Thus, the two substrates of this enzyme are pyridoxal 5'-phosphate and H₂O, whereas its two products are pyridoxal and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is pyridoxal-5'-phosphate phosphohydrolase. Other names in common use include vitamine B₆ (pyridoxine) phosphatase, PLP phosphatase, vitamin B₆-phosphate phosphatase, and PNP phosphatase. This enzyme participates in vitamin B₆ metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2CFR}}, {{PDB link|2CFS}}, {{PDB link|2CFT}}, {{PDB link|2OYC}}, {{PDB link|2P27}}, and {{PDB link|2P69}}.

References

{{cite journal | author = Fonda ML | date = 1992 | title = Purification and characterization of vitamin B₆-phosphate phosphatase from human erythrocytes | journal = J. Biol. Chem. | volume = 267 | pages = 15978–83 | pmid = 1322411 | issue = 22 }}
{{cite journal | vauthors = Fonda ML, Zhang YN | date = 1995 | title = Kinetic mechanism and divalent metal activation of human erythrocyte pyridoxal phosphatase | journal = Arch. Biochem. Biophys. | volume = 320 | pages = 345–52 | pmid = 7625842 | doi = 10.1016/0003-9861(95)90018-7 | issue = 2 }}
{{cite journal | author = OS | date = 2003 | title = Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution | journal = J. Biol. Chem. | volume = 278 | pages = 50040–6 | pmid = 14522954 | doi = 10.1074/jbc.M309619200 | last2 = Kim | first2 = DW | last3 = Kang | first3 = TC | last4 = Won | first4 = MH | last5 = Baek | first5 = NI | last6 = Moon | first6 = BJ | last7 = Choi | first7 = SY | last8 = Kwon | first8 = OS | issue = 50 }}

2 : EC 3.1.3|Enzymes of known structure

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