| 词条 | Quinagolide | ||||
| 释义 |
| Verifiedfields = changed | verifiedrevid = 464378419 | IUPAC_name = N,N-diethyl-N'-[(3S,4aS,10aR)-6-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-3-yl]sulfamide | image = Structure without stereochemistry | tradename = Norprolac | Drugs.com = {{drugs.com|international|quinagolide}} | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 87056-78-8 | ATC_prefix = G02 | ATC_suffix = CB04 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C20H33N3O3S/c1-4-10-22-14-17(21-27(25,26)23(5-2)6-3)11-16-12-18-15(13-19(16)22)8-7-9-20(18)24/h7-9,16-17,19,21,24H,4-6,10-14H2,1-3H3/t16-,17+,19-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = GDFGTRDCCWFXTG-ZIFCJYIRSA-N | PubChem = 55645 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2343034 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 80Q9QWN15M | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07217 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 290962 | C=20 | H=33 | N=3 | O=3 | S=1 | molecular_weight = 395.56 g/mol }}Quinagolide (INN, BAN; brand name Norprolac) is a selective D2 receptor agonist that is used to reduce elevated levels of prolactin (hyperprolactinemia).[1] It has also been found to be effective in the treatment of breast pain.[2] StereochemistryQuinagolide is a racemate composed of the following two enantiomers:[3]
See also
References1. ^{{cite journal |title = The effect of quinagolide and cabergoline, two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas |author1=Antonella Di Sarno |author2=Maria Luisa Landi |author3=Paolo Marzullo |author4=Carolina Di Somma |author5=Rosario Pivonello |author6=Gaetana Cerbone |author7=Gaetano Lombardi |author8=Annamaria Colao |journal = Clinical Endocrinology |volume = 53 |issue = 1 |pages = 53–60 |date=July 2000 |doi = 10.1046/j.1365-2265.2000.01016.x |pmid=10931080}} {{Dopaminergics}}{{drug-stub}}2. ^{{cite book|author=Alfonso M Pluchinotta|title=The Outpatient Breast Clinic: Aiming at Best Practice|url=https://books.google.com/books?id=m5twCAAAQBAJ&pg=PA167|date=20 April 2015|publisher=Springer|isbn=978-3-319-15907-2|pages=167–}} 3. ^Rote Liste Service GmbH (Hrsg.): Rote Liste 2017 - Arzneimittelverzeichnis für Deutschland (einschließlich EU-Zulassungen und bestimmter Medizinprodukte). Rote Liste Service GmbH, Frankfurt/Main, 2017, Aufl. 57, {{ISBN|978-3-946057-10-9}}, S. 214. 6 : Benzoquinolines|D2-receptor agonists|Phenols|Prolactin inhibitors|Tocolytics|Sulfamides |
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