| 词条 | Ranimustine |
| 释义 |
| verifiedrevid = 448120715 | IUPAC_name = Methyl 6-({[(2-chloroethyl)(nitroso)amino]carbonyl}amino)-6-deoxy-α-D-glucopyranoside | image = Ranimustine (Haworth).svg | width = 215 | tradename = Cymerin | Drugs.com = {{drugs.com|international|ranimustine}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration = IV | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 58994-96-0 | ATC_prefix = L01 | ATC_suffix = AD07 | ATC_supplemental = | PubChem = 71741 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = RYH2T97J77 | ChemSpiderID = 64785 | chemical_formula = | C=10 | H=18 | Cl=1 | N=3 | O=7 | molecular_weight = 327.71 g/mol | smiles = CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CNC(=O)N(CCCl)N=O)O)O)O | StdInChI = 1S/C10H18ClN3O7/c1-20-9-8(17)7(16)6(15)5(21-9)4-12-10(18)14(13-19)3-2-11/h5-9,15-17H,2-4H2,1H3,(H,12,18)/t5-,6-,7+,8-,9+/m1/s1 | StdInChIKey = AHHFEZNOXOZZQA-ZEBDFXRSSA-N | synonyms = 1-(2-chloroethyl)-1-nitroso-3-([(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methyl)urea }}Ranimustine (INN, marketed under the tradename Cymerin; also known as MCNU) is a nitrosourea alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia[1] and polycythemia vera.[2] It has never been filed for FDA evaluation in the United States, where it is not marketed. References1. ^{{cite journal |vauthors=Kitajima K, Adachi T, Takahashi I, etal |title=[Chemotherapy of chronic myelogenous leukemia—VP(M) regimen initiated during its chronic phase, and evaluation of MCNU in the phase of blastic crisis] |language=Japanese |journal=Gan To Kagaku Ryoho |volume=16 |issue=11 |pages=3573–9 |date=November 1989 |pmid=2817908 |doi= |url=}} 2. ^{{cite journal |vauthors=Nagai M, Tasaka T, Kamano H, etal |title=[Therapeutic effect of ranimustine (MCNU) on essential thrombocythemia and polycythemia vera] |language=Japanese |journal=Gan To Kagaku Ryoho |volume=15 |issue=12 |pages=3267–70 |date=December 1988 |pmid=3196045 |doi= |url=}}
5 : Alkylating antineoplastic agents|Nitrosamines|Nitrosoureas|Ureas|Chloroethyl compounds |
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