| 释义 |
- References
- Further reading
{{Infobox_gene}}Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM][3]
}}References1. ^{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res | volume = 3 | issue = 5 | pages = 321–9, 341–54 |date=May 1997 | pmid = 9039502 | pmc = | doi =10.1093/dnares/3.5.321 }}
2. ^{{cite journal | vauthors = Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y | title = Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1 | journal = FEBS Lett | volume = 457 | issue = 1 | pages = 85–9 |date=Oct 1999 | pmid = 10486569 | pmc = | doi =10.1016/S0014-5793(99)01012-1 }}
3. ^1 {{cite web | title = Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=de Rooij J, Rehmann H, van Triest M, etal |title=Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20829–36 |year= 2000 |pmid= 10777494 |doi= 10.1074/jbc.M001113200 }}
- {{cite journal | vauthors=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 }}
- {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Dupuy AG, L'Hoste S, Cherfils J, etal |title=Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac |journal=Oncogene |volume=24 |issue= 28 |pages= 4509–20 |year= 2005 |pmid= 15856025 |doi= 10.1038/sj.onc.1208647 }}
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