| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.[3]
}}InteractionsRASA3 has been shown to interact with HCK.[4] References1. ^{{cite journal |vauthors=Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF | title = Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family | journal = Nature | volume = 376 | issue = 6540 | pages = 527–30 |date=Sep 1995 | pmid = 7637787 | pmc = | doi = 10.1038/376527a0 | bibcode =1995Natur.376..527C }}
2. ^{{cite journal |vauthors=Lockyer PJ, Bottomley JR, Reynolds JS, McNulty TJ, Venkateswarlu K, Potter BV, Dempsey CE, Cullen PJ | title = Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting | journal = Curr Biol | volume = 7 | issue = 12 | pages = 1007–10 |date=Feb 1998 | pmid = 9382842 | pmc = | doi =10.1016/S0960-9822(06)00423-4 }}
3. ^1 {{cite web | title = Entrez Gene: RASA3 RAS p21 protein activator 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22821| accessdate = }}
4. ^{{cite journal |last=Briggs |first=S D |authorlink= |author2=Bryant S S |author3=Jove R |author4=Sanderson S D |author5=Smithgall T E |date=Jun 1995 |title=The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck |journal=J. Biol. Chem. |volume=270 |issue=24 |pages=14718–24 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 7782336 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.270.24.14718 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Hata Y, Kikuchi A, Sasaki T, etal |title=Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s |journal=J. Biol. Chem. |volume=265 |issue= 13 |pages= 7104–7 |year= 1990 |pmid= 2158984 |doi= }}
- {{cite journal |vauthors=Hjermstad SJ, Briggs SD, Smithgall TE |title=Phosphorylation of the ras GTPase-activating protein (GAP) by the p93c-fes protein-tyrosine kinase in vitro and formation of GAP-fes complexes via an SH2 domain-dependent mechanism |journal=Biochemistry |volume=32 |issue= 39 |pages= 10519–25 |year= 1993 |pmid= 7691175 |doi=10.1021/bi00090a031 }}
- {{cite journal |vauthors=Briggs SD, Bryant SS, Jove R, etal |title=The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14718–24 |year= 1995 |pmid= 7782336 |doi=10.1074/jbc.270.24.14718 }}
- {{cite journal |vauthors=Lockyer PJ, Vanlingen S, Reynolds JS, etal |title=Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1(IP4BP) and GAP1(m) |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 2 |pages= 421–6 |year= 1999 |pmid= 10049724 |doi= 10.1006/bbrc.1999.0217 }}
- {{cite journal |vauthors=El-Daher SS, Patel Y, Siddiqua A, etal |title=Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes |journal=Blood |volume=95 |issue= 11 |pages= 3412–22 |year= 2000 |pmid= 10828023 |doi= }}
- {{cite journal |vauthors=Cozier GE, Lockyer PJ, Reynolds JS, etal |title=GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28261–8 |year= 2000 |pmid= 10869341 |doi= 10.1074/jbc.M000469200 }}
- {{cite journal |vauthors=Koehler JA, Moran MF |title=RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 4 |pages= 888–95 |year= 2001 |pmid= 11350068 |doi= 10.1006/bbrc.2001.4889 }}
- {{cite journal |vauthors=Walker SA, Kupzig S, Lockyer PJ, etal |title=Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48779–85 |year= 2003 |pmid= 12356770 |doi= 10.1074/jbc.M204839200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
- {{cite journal |vauthors=Battram AM, Durrant TN, Agbani EO, etal |title=The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-binder Rasa3 Regulates Phosphoinositide 3-kinase (PI 3-kinase)-dependent Integrin αIIbβ3 Outside-in Signaling |journal=J. Biol. Chem. |year= 2016 |pmid= 27903653 |doi= 10.1074/jbc.M116.746867 |volume=292 |pmc=5290945 |pages=1691–1704}}
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