| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.[3]
}}InteractionsRASSF2 has been shown to interact with KRAS.[4] References1. ^{{cite journal |vauthors=Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N | title = Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res | volume = 3 | issue = 1 | pages = 17–24 |date=Nov 1996 | pmid = 8724849 | pmc = | doi =10.1093/dnares/3.1.17 }}
2. ^{{cite journal |vauthors=Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F | title = CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations | journal = Oncogene | volume = 24 | issue = 24 | pages = 3987–94 |date=Jun 2005 | pmid = 15806169 | pmc = | doi = 10.1038/sj.onc.1208566 }}
3. ^1 {{cite web | title = Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9770| accessdate = }}
4. ^{{cite journal |last=Vos |first=Michele D |authorlink= |author2=Ellis Chad A |author3=Elam Candice |author4=Ulku Aylin S |author5=Taylor Barbara J |author6=Clark Geoffrey J |date=Jul 2003 |title=RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor |journal=J. Biol. Chem. |volume=278 |issue=30 |pages=28045–51 |publisher= |location = United States| issn = 0021-9258| pmid = 12732644 |doi = 10.1074/jbc.M300554200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Comincini S, Castiglioni BM, Foti GM, etal |title=Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene |journal=Mamm. Genome |volume=12 |issue= 2 |pages= 150–6 |year= 2001 |pmid= 11210185 |doi=10.1007/s003350010239 }}
- {{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Vos MD, Ellis CA, Elam C, etal |title=RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28045–51 |year= 2003 |pmid= 12732644 |doi= 10.1074/jbc.M300554200 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Fujita H, Fukuhara S, Sakurai A, etal |title=Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 5022–31 |year= 2005 |pmid= 15569673 |doi= 10.1074/jbc.M409701200 }}
- {{cite journal |vauthors=Akino K, Toyota M, Suzuki H, etal |title=The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer |journal=Gastroenterology |volume=129 |issue= 1 |pages= 156–69 |year= 2005 |pmid= 16012945 |doi=10.1053/j.gastro.2005.03.051 }}
- {{cite journal |vauthors=Endoh M, Tamura G, Honda T, etal |title=RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer |journal=Br. J. Cancer |volume=93 |issue= 12 |pages= 1395–9 |year= 2006 |pmid= 16265349 |doi= 10.1038/sj.bjc.6602854 | pmc=2361541 }}
- {{cite journal |vauthors=Zhang Z, Sun D, Van do N, etal |title=Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma |journal=Int. J. Cancer |volume=120 |issue= 1 |pages= 32–8 |year= 2007 |pmid= 17013896 |doi= 10.1002/ijc.22185 }}
- {{cite journal |vauthors=Park HW, Kang HC, Kim IJ, etal |title=Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers |journal=Int. J. Cancer |volume=120 |issue= 1 |pages= 7–12 |year= 2007 |pmid= 17013898 |doi= 10.1002/ijc.22276 }}
- {{cite journal |vauthors=Kumari G, Singhal PK, Rao MR, Mahalingam S |title=Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals |journal=J. Mol. Biol. |volume=367 |issue= 5 |pages= 1294–311 |year= 2007 |pmid= 17320110 |doi= 10.1016/j.jmb.2007.01.026 }}
- {{cite journal |vauthors=Kaira K, Sunaga N, Tomizawa Y, etal |title=Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers |journal=Int. J. Oncol. |volume=31 |issue= 1 |pages= 169–73 |year= 2007 |pmid= 17549418 |doi= 10.3892/ijo.31.1.169}}
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