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词条 RBBP8
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.[1][2][3]

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.[3]

Interactions

RBBP8 has been shown to interact with:

{{div col|colwidth=20em}}
  • ATM,[4][5]
  • BRCA1,[4][8][6][7][8][9][10]
  • CTBP1,[11][12]
  • LMO4,[13][14]
  • RB1,[1][15]
  • RBL1,[1][16]
  • RBL2,[1]{[17] and
  • SIAH1[18]
{{Div col end}}

References

1. ^1 2 3 {{cite journal | vauthors = Fusco C, Reymond A, Zervos AS | title = Molecular cloning and characterization of a novel retinoblastoma-binding protein | journal = Genomics | volume = 51 | issue = 3 | pages = 351–8 | date = October 1998 | pmid = 9721205 | pmc = | doi = 10.1006/geno.1998.5368 }}
2. ^{{cite journal | vauthors = Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP | title = Human CtIP promotes DNA end resection | journal = Nature | volume = 450 | issue = 7169 | pages = 509–14 | date = November 2007 | pmid = 17965729 | pmc = 2409435 | doi = 10.1038/nature06337 }}
3. ^1 {{cite web | title = Entrez Gene: RBBP8 retinoblastoma binding protein 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5932| accessdate = }}
4. ^1 {{cite journal | vauthors = Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH | title = Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response | journal = Nature | volume = 406 | issue = 6792 | pages = 210–5 | date = July 2000 | pmid = 10910365 | doi = 10.1038/35018134 }}
5. ^{{cite journal | vauthors = Kim ST, Lim DS, Canman CE, Kastan MB | title = Substrate specificities and identification of putative substrates of ATM kinase family members | journal = J. Biol. Chem. | volume = 274 | issue = 53 | pages = 37538–43 | date = Dec 1999 | pmid = 10608806 | doi = 10.1074/jbc.274.53.37538}}
6. ^{{cite journal | vauthors = Rodriguez M, Yu X, Chen J, Songyang Z | title = Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52914–8 | date = Dec 2003 | pmid = 14578343 | doi = 10.1074/jbc.C300407200 }}
7. ^{{cite journal | vauthors = Wong AK, Ormonde PA, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian SV, Teng DH, Bartel PL | title = Characterization of a carboxy-terminal BRCA1 interacting protein | journal = Oncogene | volume = 17 | issue = 18 | pages = 2279–85 | date = November 1998 | pmid = 9811458 | doi = 10.1038/sj.onc.1202150 }}
8. ^{{cite journal | vauthors = Wu-Baer F, Baer R | title = Effect of DNA damage on a BRCA1 complex | journal = Nature | volume = 414 | issue = 6859 | pages = 36 | date = November 2001 | pmid = 11689934 | doi = 10.1038/35102118 }}
9. ^{{cite journal | vauthors = Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R | title = The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression | journal = J. Biol. Chem. | volume = 273 | issue = 39 | pages = 25388–92 | date = September 1998 | pmid = 9738006 | doi = 10.1074/jbc.273.39.25388}}
10. ^{{cite journal | vauthors = Yu X, Baer R | title = Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor | journal = J. Biol. Chem. | volume = 275 | issue = 24 | pages = 18541–9 | date = June 2000 | pmid = 10764811 | doi = 10.1074/jbc.M909494199 }}
11. ^1 {{cite journal | vauthors = Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH | title = Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11334–8 | date = April 1999 | pmid = 10196224 | doi = 10.1074/jbc.274.16.11334}}
12. ^{{cite journal | vauthors = Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G | title = Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif | journal = J. Biol. Chem. | volume = 273 | issue = 15 | pages = 8549–52 | date = April 1998 | pmid = 9535825 | doi = 10.1074/jbc.273.15.8549}}
13. ^{{cite journal | vauthors = Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE | title = The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 7849–56 | date = March 2002 | pmid = 11751867 | doi = 10.1074/jbc.M110603200 }}
14. ^{{cite journal | vauthors = Sutherland KD, Visvader JE, Choong DY, Sum EY, Lindeman GJ, Campbell IG | title = Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas | journal = Int. J. Cancer | volume = 107 | issue = 1 | pages = 155–8 | date = October 2003 | pmid = 12925972 | doi = 10.1002/ijc.11343 }}
15. ^{{cite journal | vauthors = Dick FA, Sailhamer E, Dyson NJ | title = Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3715–27 | date = May 2000 | pmid = 10779361 | pmc = 85672 | doi = 10.1128/mcb.20.10.3715-3727.2000}}
16. ^{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
17. ^{{cite journal | vauthors = Meloni AR, Smith EJ, Nevins JR | title = A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 17 | pages = 9574–9 | date = August 1999 | pmid = 10449734 | pmc = 22250 | doi = 10.1073/pnas.96.17.9574}}
18. ^{{cite journal | vauthors = Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H | title = SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway | journal = Oncogene | volume = 22 | issue = 55 | pages = 8845–51 | date = Dec 2003 | pmid = 14654780 | doi = 10.1038/sj.onc.1206994 }}

Further reading

{{Refbegin | 2}}
  • {{cite journal | vauthors = Deng CX, Brodie SG | title = Roles of BRCA1 and its interacting proteins | journal = BioEssays | volume = 22 | issue = 8 | pages = 728–37 | year = 2000 | pmid = 10918303 | doi = 10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B }}
  • {{cite journal | vauthors = Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K | title = The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression | journal = Gene | volume = 146 | issue = 2 | pages = 199–207 | year = 1994 | pmid = 8076819 | doi = 10.1016/0378-1119(94)90293-3 }}
  • {{cite journal | vauthors = Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G | title = Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif | journal = J. Biol. Chem. | volume = 273 | issue = 15 | pages = 8549–52 | year = 1998 | pmid = 9535825 | doi = 10.1074/jbc.273.15.8549 }}
  • {{cite journal | vauthors = Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R | title = The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression | journal = J. Biol. Chem. | volume = 273 | issue = 39 | pages = 25388–92 | year = 1998 | pmid = 9738006 | doi = 10.1074/jbc.273.39.25388 }}
  • {{cite journal | vauthors = Wong AK, Ormonde PA, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian SV, Teng DH, Bartel PL | title = Characterization of a carboxy-terminal BRCA1 interacting protein | journal = Oncogene | volume = 17 | issue = 18 | pages = 2279–85 | year = 1998 | pmid = 9811458 | doi = 10.1038/sj.onc.1202150 }}
  • {{cite journal | vauthors = Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH | title = Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11334–8 | year = 1999 | pmid = 10196224 | doi = 10.1074/jbc.274.16.11334 }}
  • {{cite journal | vauthors = Meloni AR, Smith EJ, Nevins JR | title = A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 17 | pages = 9574–9 | year = 1999 | pmid = 10449734 | pmc = 22250 | doi = 10.1073/pnas.96.17.9574 }}
  • {{cite journal | vauthors = Kim ST, Lim DS, Canman CE, Kastan MB | title = Substrate specificities and identification of putative substrates of ATM kinase family members | journal = J. Biol. Chem. | volume = 274 | issue = 53 | pages = 37538–43 | year = 2000 | pmid = 10608806 | doi = 10.1074/jbc.274.53.37538 }}
  • {{cite journal | vauthors = Yu X, Baer R | title = Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor | journal = J. Biol. Chem. | volume = 275 | issue = 24 | pages = 18541–9 | year = 2000 | pmid = 10764811 | doi = 10.1074/jbc.M909494199 }}
  • {{cite journal | vauthors = Dick FA, Sailhamer E, Dyson NJ | title = Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral Oncoproteins | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3715–27 | year = 2000 | pmid = 10779361 | pmc = 85672 | doi = 10.1128/MCB.20.10.3715-3727.2000 }}
  • {{cite journal | vauthors = Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C | title = Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb | journal = FASEB J. | volume = 14 | issue = 7 | pages = 904–12 | year = 2000 | pmid = 10783144 | doi = 10.1096/fasebj.14.7.904}}
  • {{cite journal | vauthors = Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH | title = Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response | journal = Nature | volume = 406 | issue = 6792 | pages = 210–5 | year = 2000 | pmid = 10910365 | doi = 10.1038/35018134 }}
  • {{cite journal | vauthors = Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH | title = Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1 | journal = Mol. Cell | volume = 6 | issue = 4 | pages = 757–68 | year = 2000 | pmid = 11090615 | doi = 10.1016/S1097-2765(00)00075-7 }}
  • {{cite journal | vauthors = Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H | title = The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling | journal = Blood | volume = 97 | issue = 9 | pages = 2815–22 | year = 2001 | pmid = 11313276 | doi = 10.1182/blood.V97.9.2815 }}
  • {{cite journal | vauthors = Melhuish TA, Gallo CM, Wotton D | title = TGIF2 interacts with histone deacetylase 1 and represses transcription | journal = J. Biol. Chem. | volume = 276 | issue = 34 | pages = 32109–14 | year = 2001 | pmid = 11427533 | doi = 10.1074/jbc.M103377200 }}
  • {{cite journal | vauthors = Wu-Baer F, Baer R | title = Effect of DNA damage on a BRCA1 complex | journal = Nature | volume = 414 | issue = 6859 | pages = 36 | year = 2001 | pmid = 11689934 | doi = 10.1038/35102118 }}
  • {{cite journal | vauthors = Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE | title = The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 7849–56 | year = 2002 | pmid = 11751867 | doi = 10.1074/jbc.M110603200 }}
  • {{cite journal | vauthors = Koipally J, Georgopoulos K | title = Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression | journal = J. Biol. Chem. | volume = 277 | issue = 26 | pages = 23143–9 | year = 2002 | pmid = 11959865 | doi = 10.1074/jbc.M202079200 }}
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