| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.[1][2] Function The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.[2] Interactions RBM39 has been shown to interact with Estrogen receptor alpha,[3] Estrogen receptor beta[3] and C-jun.[3] References 1. ^{{cite journal | vauthors = Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM | title = Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma | journal = J Clin Invest | volume = 92 | issue = 5 | pages = 2419–26 | date = Dec 1993 | pmid = 8227358 | pmc = 288425 | doi = 10.1172/JCI116848 }}
2. ^1 {{cite web | title = Entrez Gene: RBM39 RNA binding motif protein 39| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9584| accessdate = }}
3. ^1 2 {{cite journal | vauthors = Jung DJ, Na SY, Na DS, Lee JW | title = Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors | journal = J. Biol. Chem. | volume = 277 | issue = 2 | pages = 1229–34 | date = Jan 2002 | pmid = 11704680 | doi = 10.1074/jbc.M110417200 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Jung DJ, Na SY, Na DS, Lee JW | title = Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors | journal = J. Biol. Chem. | volume = 277 | issue = 2 | pages = 1229–34 | year = 2002 | pmid = 11704680 | doi = 10.1074/jbc.M110417200 }}
- {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | year = 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}
- {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
- {{cite journal | vauthors = Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O'Malley BW | title = Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta | journal = Mol. Cell | volume = 17 | issue = 3 | pages = 429–39 | year = 2005 | pmid = 15694343 | doi = 10.1016/j.molcel.2004.12.025 }}
- {{cite journal | vauthors = Sun NN, Fastje CD, Wong SS, Sheppard PR, Macdonald SJ, Ridenour G, Hyde JD, Witten ML | title = Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line | journal = Toxicology and industrial health | volume = 19 | issue = 7–10 | pages = 157–63 | year = 2005 | pmid = 15747776 | doi = 10.1191/0748233703th185oa }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
{{refend}}{{PDB Gallery|geneid=9584}}{{gene-20-stub}} |