1. Function

2. See also

3. References

4. Further reading

Function

Rbfox2 is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative splicing in the nervous system and other cell types. Rbfox2 and the related protein Rbfox1 bind to conserved (U)GCAUG RNA motifs in the introns adjacent to many alternatively spliced exons and promotes inclusion or exclusion of the alternative exon in mature transcripts.^[2][3] The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

Rbfox2, as determined by CLIP-seq, binds near alternatively spliced exons and regulates the inclusion or exclusion of exons during alternative splicing by binding in introns either downstream (inclusion) or upstream (exon skipping) of exons. Its presence is important for stem cell survival and knockdowns of Rbfox2 activate markers for apoptosis.^[4]

See also

• Alternative splicing
• RNA-binding protein

References

Further reading

• {{cite journal | author=Dunham I |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–495 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |name-list-format=vanc| author2=Shimizu N | author3=Roe BA | display-authors=3 | last4=Bruskiewich | first4=R. | last5=Beare | first5=D. M. | last6=Clamp | first6=M. | last7=Smink | first7=L. J. | last8=Ainscough | first8=R. | last9=Almeida | first9=J. P. }}
• {{cite journal | author=Lieberman AP |title=Androgens regulate the mammalian homologues of invertebrate sex determination genes tra-2 and fox-1 |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 2 |pages= 499–506 |year= 2001 |pmid= 11401487 |doi= 10.1006/bbrc.2001.4617 |name-list-format=vanc| author2=Friedlich DL | author3=Harmison G | display-authors=3 | last4=Howell | first4=BW | last5=Jordan | first5=CL | last6=Breedlove | first6=SM | last7=Fischbeck | first7=KH }}
• {{cite journal |vauthors=Norris JD, Fan D, Sherk A, McDonnell DP |title=A negative coregulator for the human ER |journal=Mol. Endocrinol. |volume=16 |issue= 3 |pages= 459–468 |year= 2002 |pmid= 11875103 |doi=10.1210/me.16.3.459 }}
• {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
• {{cite journal | author=Collins JE |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22 |journal=Genome Res. |volume=13 |issue= 1 |pages= 27–36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 | pmc=430954 |name-list-format=vanc| author2=Goward ME | author3=Cole CG | display-authors=3 | last4=Smink | first4=LJ | last5=Huckle | first5=EJ | last6=Knowles | first6=S | last7=Bye | first7=JM | last8=Beare | first8=DM | last9=Dunham | first9=I }}
• {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}
• {{cite journal | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |name-list-format=vanc| author2=Wright CL | author3=Edwards CA | display-authors=3 | last4=Davis | first4=Matthew P | last5=Grinham | first5=James A | last6=Cole | first6=Charlotte G | last7=Goward | first7=Melanie E | last8=Aguado | first8=Begoña | last9=Mallya | first9=Meera }}
• {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
• {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }}
• {{cite journal | author=Underwood JG |title=Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals |journal=Mol. Cell. Biol. |volume=25 |issue= 22 |pages= 10005–10016 |year= 2005 |pmid= 16260614 |doi= 10.1128/MCB.25.22.10005-10016.2005 | pmc=1280273 |name-list-format=vanc| author2=Boutz PL | author3=Dougherty JD | display-authors=3 | last4=Stoilov | first4=P. | last5=Black | first5=D. L. }}
• {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-format=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
• {{cite journal | author=Ponthier JL |title=Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16 |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12468–12474 |year= 2006 |pmid= 16537540 |doi= 10.1074/jbc.M511556200 |name-list-format=vanc| author2=Schluepen C | author3=Chen W | display-authors=3 | last4=Lersch | first4=RA | last5=Gee | first5=SL | last6=Hou | first6=VC | last7=Lo | first7=AJ | last8=Short | first8=SA | last9=Chasis | first9=JA }}
• {{cite journal | author=Lim J |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–814 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |name-list-format=vanc| author2=Hao T | author3=Shaw C | display-authors=3 | last4=Patel | first4=Akash J. | last5=Szabó | first5=Gábor | last6=Rual | first6=Jean-François | last7=Fisk | first7=C. Joseph | last8=Li | first8=Ning | last9=Smolyar | first9=Alex }}

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