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词条 RBP1
释义

  1. Function

  2. Clinical significance

  3. References

  4. Further reading

{{Infobox_gene}}Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene.[1][1][2]

Function

RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.[3]

Clinical significance

Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiative state of endometrial cells through the regulation of bioavailability of retinol. On the converse, loss of CRBP-1 is associated with development of endometrial cancer.[4]

References

1. ^{{cite journal | vauthors = Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ | title = Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro | journal = J. Biol. Chem. | volume = 266 | issue = 26 | pages = 17662–6 |date=September 1991 | pmid = 1654334 | doi = | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=1654334 | issn = }}
2. ^{{cite journal | vauthors = De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L | title = Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 82 | issue = 3-4 | pages = 226–7 | year = 1998 | pmid = 9858824 | doi = 10.1159/000015107| url = }}
3. ^{{cite web | title = Entrez Gene: RBP1 retinol binding protein 1, cellular| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5947| accessdate = }}
4. ^{{cite journal | vauthors = Orlandi A, Ferlosio A, Ciucci A, Francesconi A, Lifschitz-Mercer B, Gabbiani G, Spagnoli LG, Czernobilsky B | title = Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications | journal = Mod. Pathol. | volume = 19 | issue = 6 | pages = 797–803 |date=June 2006 | pmid = 16575402 | doi = 10.1038/modpathol.3800586 | url = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Herr FM, Ong DE |title=Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins. |journal=Biochemistry |volume=31 |issue= 29 |pages= 6748–55 |year= 1992 |pmid= 1322170 |doi=10.1021/bi00144a014 }}
  • {{cite journal |vauthors=Siegenthaler G, Tomatis I, Chatellard-Gruaz D, etal |title=Expression of CRABP-I and -II in human epidermal cells. Alteration of relative protein amounts is linked to the state of differentiation. | series=287 |journal=Biochem. J. |volume=( Pt 2) |issue= |pages= 383–9 |year= 1992 |pmid= 1332671 |doi= | pmc=1133176 }}
  • {{cite journal |vauthors=Aström A, Tavakkol A, Pettersson U, etal |title=Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. |journal=J. Biol. Chem. |volume=266 |issue= 26 |pages= 17662–6 |year= 1991 |pmid= 1654334 |doi= }}
  • {{cite journal | vauthors=Wei LN, Mertz JR, Goodman DS, Nguyen-Huu MC |title=Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression. |journal=Mol. Endocrinol. |volume=1 |issue= 8 |pages= 526–34 |year= 1990 |pmid= 2856408 |doi=10.1210/mend-1-8-526 }}
  • {{cite journal |vauthors=Colantuoni V, Cortese R, Nilsson M, etal |title=Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=130 |issue= 1 |pages= 431–9 |year= 1985 |pmid= 2992469 |doi=10.1016/0006-291X(85)90435-8 }}
  • {{cite journal |vauthors=Nilsson MH, Spurr NK, Lundvall J, etal |title=Human cellular retinol-binding protein gene organization and chromosomal location. |journal=Eur. J. Biochem. |volume=173 |issue= 1 |pages= 35–44 |year= 1988 |pmid= 3356192 |doi=10.1111/j.1432-1033.1988.tb13963.x }}
  • {{cite journal | vauthors=Sherman DR, Lloyd RS, Chytil F |title=Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 10 |pages= 3209–13 |year= 1987 |pmid= 3472205 |doi=10.1073/pnas.84.10.3209 | pmc=304838 }}
  • {{cite journal |vauthors=Kooistra T, Lansink M, Arts J, etal |title=Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells. |journal=Eur. J. Biochem. |volume=232 |issue= 2 |pages= 425–32 |year= 1995 |pmid= 7556191 |doi=10.1111/j.1432-1033.1995.425zz.x }}
  • {{cite journal |vauthors=Jaconi S, Rose K, Hughes GJ, etal |title=Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure. |journal=J. Lipid Res. |volume=36 |issue= 6 |pages= 1247–53 |year= 1995 |pmid= 7666002 |doi= }}
  • {{cite journal |vauthors=Liu W, Hellman P, Li Q, etal |title=Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells. |journal=Biochem. Biophys. Res. Commun. |volume=229 |issue= 3 |pages= 922–9 |year= 1997 |pmid= 9005841 |doi= 10.1006/bbrc.1996.1903 }}
  • {{cite journal | vauthors=Sundaram M, Sivaprasadarao A, DeSousa MM, Findlay JB |title=The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3336–42 |year= 1998 |pmid= 9452451 |doi=10.1074/jbc.273.6.3336 }}
  • {{cite journal |vauthors=De Baere E, Speleman F, Van Roy N, etal |title=Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 3-4 |pages= 226–7 |year= 1999 |pmid= 9858824 |doi=10.1159/000015107 }}
  • {{cite journal |vauthors=Christensen EI, Moskaug JO, Vorum H, etal |title=Evidence for an essential role of megalin in transepithelial transport of retinol. |journal=J. Am. Soc. Nephrol. |volume=10 |issue= 4 |pages= 685–95 |year= 1999 |pmid= 10203351 |doi= }}
  • {{cite journal |vauthors=Skowyra D, Zeremski M, Neznanov N, etal |title=Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8734–9 |year= 2001 |pmid= 11118440 |doi= 10.1074/jbc.M007664200 }}
  • {{cite journal |vauthors=Folli C, Calderone V, Ottonello S, etal |title=Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 7 |pages= 3710–5 |year= 2001 |pmid= 11274389 |doi= 10.1073/pnas.061455898 | pmc=31117 }}
  • {{cite journal |vauthors=Orlandi A, Francesconi A, Clément S, etal |title=High levels of cellular retinol binding protein-1 expression in leiomyosarcoma: possible implications for diagnostic evaluation. |journal=Virchows Arch. |volume=441 |issue= 1 |pages= 31–40 |year= 2002 |pmid= 12111198 |doi= 10.1007/s00428-001-0576-7 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal | vauthors=Cvetković D, Williams SJ, Hamilton TC |title=Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer. |journal=Clin. Cancer Res. |volume=9 |issue= 3 |pages= 1013–20 |year= 2003 |pmid= 12631600 |doi= }}
  • {{cite journal |vauthors=Hosaka B, Park SI, Felipe CR, etal |title=Predictive value of urinary retinol binding protein for graft dysfunction after kidney transplantation. |journal=Transplant. Proc. |volume=35 |issue= 4 |pages= 1341–3 |year= 2004 |pmid= 12826154 |doi=10.1016/S0041-1345(03)00380-4 }}
  • {{cite journal |vauthors=Schmitt-Gräff A, Ertelt V, Allgaier HP, etal |title=Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival. |journal=Hepatology |volume=38 |issue= 2 |pages= 470–80 |year= 2003 |pmid= 12883492 |doi= 10.1053/jhep.2003.50321 }}
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