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词条 RDBP
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

  5. External links

{{Infobox_gene}}Negative elongation factor E is a protein that in humans is encoded by the RDBP gene.[1]

Function

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.[1]

Interactions

RDBP has been shown to interact with:

  • Cofactor of BRCA1,[3][2]
  • TH1L,[3][4] and
  • WHSC2.[4]

References

1. ^1 {{cite web | title = Entrez Gene: RDBP RD RNA binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7936| accessdate = }}
2. ^{{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | date = Jan 2004 | pmid = 14667819 | doi = 10.1016/s0888-7543(03)00235-0}}
3. ^{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 | year=2007}}
4. ^1 2 {{cite journal | vauthors = Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H | title = Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 1863–73 | date = Mar 2003 | pmid = 12612062 | pmc = 149481 | doi = 10.1128/mcb.23.6.1863-1873.2003}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Yu CY | title = Molecular genetics of the human MHC complement gene cluster | journal = Experimental and Clinical Immunogenetics | volume = 15 | issue = 4 | pages = 213–30 | year = 1999 | pmid = 10072631 | doi = 10.1159/000019075 }}
  • {{cite journal | vauthors = Stevens M, De Clercq E, Balzarini J | title = The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention | journal = Medicinal Research Reviews | volume = 26 | issue = 5 | pages = 595–625 | date = Sep 2006 | pmid = 16838299 | doi = 10.1002/med.20081 }}
  • {{cite journal | vauthors = Surowy CS, Hoganson G, Gosink J, Strunk K, Spritz RA | title = The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved | journal = Gene | volume = 90 | issue = 2 | pages = 299–302 | date = Jun 1990 | pmid = 2119325 | doi = 10.1016/0378-1119(90)90194-V }}
  • {{cite journal | vauthors = Speiser PW, White PC | title = Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex | journal = Dna | volume = 8 | issue = 10 | pages = 745–51 | date = Dec 1989 | pmid = 2612324 | doi = 10.1089/dna.1989.8.745 }}
  • {{cite journal | vauthors = Lévi-Strauss M, Carroll MC, Steinmetz M, Meo T | title = A previously undetected MHC gene with an unusual periodic structure | journal = Science | volume = 240 | issue = 4849 | pages = 201–4 | date = Apr 1988 | pmid = 3353717 | doi = 10.1126/science.3353717 }}
  • {{cite journal | vauthors = Cheng J, Macon KJ, Volanakis JE | title = cDNA cloning and characterization of the protein encoded by RD, a gene located in the class III region of the human major histocompatibility complex | journal = The Biochemical Journal | volume = 294 | issue = 2 | pages = 589–93 | date = Sep 1993 | pmid = 8373374 | pmc = 1134496 | doi = 10.1042/bj2940589}}
  • {{cite journal | vauthors = Lee SG, Song K | title = Genomic organization of the human DDX13 gene located between RD and RP1 in the class III MHC complex | journal = Molecules and Cells | volume = 7 | issue = 3 | pages = 414–8 | date = Jun 1997 | pmid = 9264031 | doi = }}
  • {{cite journal | vauthors = Büssow K, Cahill D, Nietfeld W, Bancroft D, Scherzinger E, Lehrach H, Walter G | title = A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library | journal = Nucleic Acids Research | volume = 26 | issue = 21 | pages = 5007–8 | date = Nov 1998 | pmid = 9776767 | pmc = 147919 | doi = 10.1093/nar/26.21.5007 }}
  • {{cite journal | vauthors = Yang Z, Shen L, Dangel AW, Wu LC, Yu CY | title = Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA | journal = Genomics | volume = 53 | issue = 3 | pages = 338–47 | date = Nov 1998 | pmid = 9799600 | doi = 10.1006/geno.1998.5499 }}
  • {{cite journal | vauthors = Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, Hasegawa J, Handa H | title = NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation | journal = Cell | volume = 97 | issue = 1 | pages = 41–51 | date = Apr 1999 | pmid = 10199401 | doi = 10.1016/S0092-8674(00)80713-8 }}
  • {{cite journal | vauthors = Ping YH, Rana TM | title = DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 16 | pages = 12951–8 | date = Apr 2001 | pmid = 11112772 | doi = 10.1074/jbc.M006130200 }}
  • {{cite journal | vauthors = Yamaguchi Y, Inukai N, Narita T, Wada T, Handa H | title = Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 2918–27 | date = May 2002 | pmid = 11940650 | pmc = 133766 | doi = 10.1128/MCB.22.9.2918-2927.2002 }}
  • {{cite journal | vauthors = Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H | title = Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 1863–73 | date = Mar 2003 | pmid = 12612062 | pmc = 149481 | doi = 10.1128/MCB.23.6.1863-1873.2003 }}
  • {{cite journal | vauthors = Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L | title = Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse | journal = Genome Research | volume = 13 | issue = 12 | pages = 2621–36 | date = Dec 2003 | pmid = 14656967 | pmc = 403804 | doi = 10.1101/gr.1736803 }}
  • {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | date = Jan 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}
  • {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
  • {{cite journal | vauthors = Aiyar SE, Sun JL, Blair AL, Moskaluk CA, Lu YZ, Ye QN, Yamaguchi Y, Mukherjee A, Ren DM, Handa H, Li R | title = Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor | journal = Genes & Development | volume = 18 | issue = 17 | pages = 2134–46 | date = Sep 2004 | pmid = 15342491 | pmc = 515291 | doi = 10.1101/gad.1214104 }}
{{refend}}

External links

  • {{FactorBook|NELFe}}
{{PDB Gallery|geneid=7936}}{{gene-6-stub}}
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