| 释义 |
- References
- Further reading
{{Infobox_gene}}Regenerating islet-derived protein 3 alpha (or Regenerating islet-derived protein III-alpha) formerly known as HIP/PAP (Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-Associated Protein) and peptide 23[1] is a protein that in humans is encoded by the REG3A gene.[2][3]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Multiple alternatively spliced transcript variants encoding the same protein have been described for this gene but the full length nature of some transcripts is not yet known.[3]
}}Reg3A ([https://www.uniprot.org/uniprot/Q06141 UniProt Q0614] 1) is a bactericidal C-type lectin that is constitutively produced in the intestine that has antibacterial properties against Gram-positive bacteria. Bacterial killing is mediated by binding to surface-exposed carbohydrate moieties of bacterial peptidoglycan.[4][5] References1. ^{{cite journal |vauthors=Chakraborty C, Sharma S, Katsumata N, Murphy LJ, Schroedter IC, Robertson MC, Shiu RP, Friesen HG | title = Plasma clearance, tissue uptake and expression of pituitary peptide 23/pancreatitis-associated protein in the rat. | journal = Journal of Endocrinology | volume = 145 | issue = 3 | pages = 461–9 | date=Jun 1995 | pmid = 7636430| doi = 10.1677/joe.0.1450461 }}
2. ^{{cite journal |vauthors=Dusetti NJ, Frigerio JM, Fox MF, Swallow DM, Dagorn JC, Iovanna JL | title = Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene | journal = Genomics | volume = 19 | issue = 1 | pages = 108–14 |date=Jun 1994 | pmid = 8188210 | pmc = | doi = 10.1006/geno.1994.1019 }}
3. ^1 {{cite web | title = Entrez Gene: REG3A regenerating islet-derived 3 alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5068| accessdate = }}
4. ^{{Cite journal|last=Cash|first=Heather L.|last2=Whitham|first2=Cecilia V.|last3=Behrendt|first3=Cassie L.|last4=Hooper|first4=Lora V.|date=2006-08-25|title=Symbiotic bacteria direct expression of an intestinal bactericidal lectin|journal=Science|volume=313|issue=5790|pages=1126–1130|doi=10.1126/science.1127119|issn=1095-9203|pmc=2716667|pmid=16931762}}
5. ^{{Cite journal|last=Vaishnava|first=Shipra|last2=Yamamoto|first2=Miwako|last3=Severson|first3=Kari M.|last4=Ruhn|first4=Kelly A.|last5=Yu|first5=Xiaofei|last6=Koren|first6=Omry|last7=Ley|first7=Ruth|last8=Wakeland|first8=Edward K.|last9=Hooper|first9=Lora V.|date=2011-10-14|title=The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine|journal=Science|volume=334|issue=6053|pages=255–258|doi=10.1126/science.1209791|issn=0036-8075|pmc=3321924|pmid=21998396}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Lasserre C, Christa L, Simon MT, etal |title=A novel gene (HIP) activated in human primary liver cancer |journal=Cancer Res. |volume=52 |issue= 18 |pages= 5089–95 |year= 1992 |pmid= 1325291 |doi= }}
- {{cite journal |vauthors=Orelle B, Keim V, Masciotra L, etal |title=Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases |journal=J. Clin. Invest. |volume=90 |issue= 6 |pages= 2284–91 |year= 1993 |pmid= 1469087 |doi=10.1172/JCI116115 | pmc=443380 }}
- {{cite journal |vauthors=Itoh T, Teraoka H |title=Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP) |journal=Biochim. Biophys. Acta |volume=1172 |issue= 1–2 |pages= 184–6 |year= 1993 |pmid= 7679928 |doi= 10.1016/0167-4781(93)90290-t}}
- {{cite journal |vauthors=Itoh T, Sawabu N, Motoo Y, etal |title=The human pancreatitis-associated protein (PAP)-encoding gene generates multiple transcripts through alternative use of 5' exons |journal=Gene |volume=155 |issue= 2 |pages= 283–7 |year= 1995 |pmid= 7721106 |doi=10.1016/0378-1119(94)00799-X }}
- {{cite journal |vauthors=Lasserre C, Simon MT, Ishikawa H, etal |title=Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer |journal=Eur. J. Biochem. |volume=224 |issue= 1 |pages= 29–38 |year= 1994 |pmid= 8076648 |doi=10.1111/j.1432-1033.1994.tb19991.x }}
- {{cite journal |vauthors=Christa L, Carnot F, Simon MT, etal |title=HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells |journal=Am. J. Physiol. |volume=271 |issue= 6 Pt 1 |pages= G993–1002 |year= 1997 |pmid= 8997243 |doi= 10.1152/ajpgi.1996.271.6.G993}}
- {{cite journal |vauthors=Rafaeloff R, Pittenger GL, Barlow SW, etal |title=Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters |journal=J. Clin. Invest. |volume=99 |issue= 9 |pages= 2100–9 |year= 1997 |pmid= 9151782 |doi=10.1172/JCI119383 | pmc=508040 }}
- {{cite journal |vauthors=Bödeker H, Keim V, Fiedler F, etal |title=PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha |journal=Mol. Cell Biol. Res. Commun. |volume=2 |issue= 3 |pages= 150–4 |year= 2000 |pmid= 10662590 |doi= 10.1006/mcbr.1999.0166 }}
- {{cite journal |vauthors=Graf R, Schiesser M, Scheele GA, etal |title=A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21028–38 |year= 2001 |pmid= 11278730 |doi= 10.1074/jbc.M010717200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Simon MT, Pauloin A, Normand G, etal |title=HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway |journal=FASEB J. |volume=17 |issue= 11 |pages= 1441–50 |year= 2003 |pmid= 12890698 |doi= 10.1096/fj.02-1013com }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Lieu HT, Batteux F, Simon MT, etal |title=HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice |journal=Hepatology |volume=42 |issue= 3 |pages= 618–26 |year= 2005 |pmid= 16116631 |doi= 10.1002/hep.20845 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
- {{cite journal |vauthors=Cash HL, Whitham CV, Behrendt CL, Hooper LV |title=Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin |journal=Science |volume=313 |issue= 5790 |pages= 1126–30 |year= 2006 |pmid= 16931762 |doi= 10.1126/science.1127119 | pmc=2716667 }}
- {{cite journal |vauthors=Ho MR, Lou YC, Lin WC, etal |title=Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation |journal=J. Biol. Chem. |volume=281 |issue= 44 |pages= 33566–76 |year= 2006 |pmid= 16963458 |doi= 10.1074/jbc.M604513200 }}
{{refend}}{{PDB Gallery|geneid=5068}}{{gene-2-stub}} |