“REM rebound”的意思、由来-开放百科全书

After early research connected rapid eye movement with dreaming and established that it made up about 20% of normal human sleep, experimenters started depriving test subjects of only REM sleep, to test its unique importance. Every time a subject's electroencephalogram and eye movements indicated the beginning of REM sleep, the experimenter would thoroughly wake them for several minutes. As this “dream deprivation” continued, tendency to initiate REM increased, and the subjects were woken up more and more times each night. The subjects became irritable, anxious, and hungry, and several left the study early. After five nights, the remaining subjects were allowed to sleep undisturbed, and showed a significant increase in percentage of sleep devoted to REM: from an average of 19.4% to an average of 26.6%. These effects were significant in comparison with a control group woken up on an equal number of occasions each night, at arbitrary times.^[3]

The fact that REM rebound exists shows that sleep and achievement of specific sleep stages are needed by the brain. In some marine animals, such as dolphins and fur seals, when one brain hemisphere is deprived of REM sleep, only the deprived hemisphere will go into REM rebound. The other hemisphere will be unaffected.^[2]

REM rebound is common to those who take certain sleeping aids and it is also often seen in the first few nights after patients with sleep apnea are placed on CPAP. Alcohol can also affect REM sleep; it suppresses it during the first half of the night, leading to a rebound four to five hours after sleep onset.^[4] Although alcohol can decrease the amount of time it takes to fall asleep, it will cause a disruption in the sleep cycles. REM sleep is decreased during the first half of the sleep period and stage 1 sleep is increased in the second half of the sleep period.^[5] Most antidepressants, in particular selective serotonin re-uptake inhibitors (SSRIs), such as citalopram and paroxetine, are potent inhibitors of REM sleep and may also cause a REM rebound on discontinuation.^[6]^[7]

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References

1. ^{{cite book |title=Psychology |last=Myers |first= David |authorlink=David Myers (academic) |edition=7th |year=2004 |publisher=Worth Publishers |location=New York |isbn=0-7167-8595-1 |page=276 |url=https://books.google.com/books?id=oYuBwPDsQZoC&lpg=PP1&ots=uCYMJ89RpT&dq=0716785951&pg=PA277 |accessdate=2010-01-09}}
2. ^¹{{cite book|last=Carlson|first=Neil R.|title=Physiology of behavior|date=2013|publisher=Pearson|location=Boston|isbn=9780205239399|edition=11th}}
3. ^William Dement, “The Effect of Dream Deprivation: The need for a certain amount of dreaming each night is suggested by recent experiments.” Science 131.3415, 10 June 1960.
4. ^{{cite web|title=Sleep, Sleepiness, and Alcohol Use|url=http://pubs.niaaa.nih.gov/publications/arh25-2/101-109.htm|publisher=National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health|accessdate=3 Nov 2011|author1=Timothy Roehrs |author2=Thomas Roth |last-author-amp=yes |date=Feb 25, 2011}}
5. ^{{cite web|title=Does Drinking Alcohol Affect Sleep?|url=http://adcaps.wsu.edu/campaigns/sleep-alcohol/|work=Alcohol & Drug Counseling, Assessment, & Prevention Services, WSU|publisher=Washington State University|accessdate=7 May 2014}}
6. ^{{Cite journal|last=McCarthy|first=Andrew|last2=Wafford|first2=Keith|last3=Shanks|first3=Elaine|last4=Ligocki|first4=Marcin|last5=Edgar|first5=Dale M.|last6=Dijk|first6=Derk-Jan|date=2016-09-01|title=REM sleep homeostasis in the absence of REM sleep: Effects of antidepressants|url=http://www.sciencedirect.com/science/article/pii/S0028390816301873|journal=Neuropharmacology|volume=108|pages=415–425|doi=10.1016/j.neuropharm.2016.04.047}}
7. ^{{Cite journal|last=Pace-Schott|first=E. F.|last2=Gersh|first2=T.|last3=Silvestri|first3=R.|last4=Stickgold|first4=R.|last5=Salzman|first5=C.|last6=Hobson|first6=J. A.|date=June 2001|title=SSRI treatment suppresses dream recall frequency but increases subjective dream intensity in normal subjects|journal=Journal of Sleep Research|volume=10|issue=2|pages=129–142|issn=0962-1105|pmid=11422727|doi=10.1046/j.1365-2869.2001.00249.x}}

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