| 释义 |
- Function
- References
- Further reading
- External links
{{Infobox_gene}}The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.[1][2][3] Function The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.[4] This protein is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[3] References1. ^{{cite journal | vauthors = Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H | title = Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules | journal = J Biol Chem | volume = 273 | issue = 18 | pages = 10939–47 |date=Jun 1998 | pmid = 9556572 | pmc = | doi =10.1074/jbc.273.18.10939 }}
2. ^{{cite journal | vauthors = Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB | title = Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4) | journal = Mol Vis | volume = 7 | issue = | pages = 234–9 |date=Oct 2001 | pmid = 11590366 | pmc = | doi = }}
3. ^1 {{cite web | title = Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10159| accessdate = }}
4. ^{{cite journal | vauthors = Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD | title = Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin | journal = J. Clin. Invest. | volume = 109 | issue = 11 | pages = 1417–27 |date=June 2002 | pmid = 12045255 | pmc = 150992 | doi = 10.1172/JCI14276 | url = | issn = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Kaneshiro Y, Ichihara A, Sakoda M |title=Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats |journal=J. Am. Soc. Nephrol. |volume=18 |issue= 6 |pages= 1789–95 |year= 2007 |pmid= 17494887 |doi= 10.1681/ASN.2006091062 |display-authors=etal}}
- {{cite journal | vauthors=Schefe JH, Menk M, Reinemund J |title=A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein |journal=Circ. Res. |volume=99 |issue= 12 |pages= 1355–66 |year= 2007 |pmid= 17082479 |doi= 10.1161/01.RES.0000251700.00994.0d |display-authors=etal}}
- {{cite journal | vauthors=Kaneshiro Y, Ichihara A, Takemitsu T |title=Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats |journal=Kidney Int. |volume=70 |issue= 4 |pages= 641–6 |year= 2006 |pmid= 16807542 |doi= 10.1038/sj.ki.5001627 |display-authors=etal}}
- {{cite journal | vauthors=Burcklé CA, Jan Danser AH, Müller DN |title=Elevated blood pressure and heart rate in human renin receptor transgenic rats |journal=Hypertension |volume=47 |issue= 3 |pages= 552–6 |year= 2006 |pmid= 16401765 |doi= 10.1161/01.HYP.0000199912.47657.04 |display-authors=etal}}
- {{cite journal | vauthors=Huang Y, Wongamorntham S, Kasting J |title=Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms |journal=Kidney Int. |volume=69 |issue= 1 |pages= 105–13 |year= 2006 |pmid= 16374430 |doi= 10.1038/sj.ki.5000011 |display-authors=etal}}
- {{cite journal | vauthors=Otsuki T, Ota T, Nishikawa T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |display-authors=etal}}
- {{cite journal | vauthors=Ramser J, Abidi FE, Burckle CA |title=A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 1019–27 |year= 2005 |pmid= 15746149 |doi= 10.1093/hmg/ddi094 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Hedera P, Alvarado D, Beydoun A, Fink JK |title=Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4 |journal=Ann. Neurol. |volume=51 |issue= 1 |pages= 45–50 |year= 2002 |pmid= 11782983 |doi=10.1002/ana.10051 }}
- {{cite journal | vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |display-authors=etal}}
{{refend}}External links- {{UCSC genome browser|ATP6AP2}}
- {{UCSC gene details|ATP6AP2}}
{{gene-X-stub}} 1 : Transmembrane receptors |