“Repulsive guidance molecule”的意思、由来-开放百科全书

词条

Repulsive guidance molecule

释义

Family members
References

Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin).

RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide retinal ganglion cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth.^[1]

Family members

{{infobox protein

Name = RGM domain family, member A

caption =

image =

width =

HGNCid = 30308

Symbol = RGMA

AltSymbols = RGM

EntrezGene = 56963

OMIM = 607362

RefSeq = NM_020211

UniProt = Q96B86

PDB =

ECnumber =

Chromosome = 15

Arm = q

Band = 26.1

LocusSupplementaryData =
}}

{{infobox protein

Name = RGM domain family, member B

caption =

image =

width =

HGNCid = 26896

Symbol = RGMB

AltSymbols = DRAGON

EntrezGene = 285704

OMIM = 612687

RefSeq = NM_173670

UniProt = Q6NW40

PDB =

ECnumber =

Chromosome = 5

Arm = q

Band = 21.1

LocusSupplementaryData =
}}

{{infobox protein

Name = hemochromatosis type 2

caption =

image =

width =

HGNCid = 4887

Symbol = HFE2

AltSymbols = RGMC, HJV, hemojuvelin

EntrezGene = 148738

OMIM = 608374

RefSeq = NM_145277

UniProt = Q6ZVN8

PDB =

ECnumber =

Chromosome = 1

Arm = q

Band = 21.2

LocusSupplementaryData =
}}

References

1. ^{{cite journal |vauthors=Severyn CJ, Shinde U, Rotwein P | title = Molecular biology, genetics and biochemistry of the repulsive guidance molecule family | journal = Biochem. J. | volume = 422 | issue = 3 | pages = 393–403 |date=September 2009 | pmid = 19698085 | doi = 10.1042/BJ20090978 | url = | issn = | pmc = 4242795 }}

2 : Proteins|Developmental biology

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