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词条 Repulsive guidance molecule B
释义

  1. Function

  2. References

  3. Further reading

{{Infobox_gene}}Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family.[1] In humans this protein is encoded by the RGMB gene.[2]

Function

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see also RGMA and RGMC) and contributes to the patterning of the developing nervous system.[3][4]

There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling.[5][6] Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.[7]

References

1. ^{{cite journal|last1=Corradini|first1=Elena|last2=Babitt|first2=Jodie L.|last3=Lin|first3=Herbert Y.|title=The RGM/DRAGON family of BMP co-receptors|journal=Cytokine & Growth Factor Reviews|date=October 2009|volume=20|issue=5–6|pages=389–398|doi=10.1016/j.cytogfr.2009.10.008|pmid=19897400|pmc=3715994}}
2. ^{{cite web | title = Entrez Gene: RGM domain family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=285704| accessdate = }}
3. ^{{cite journal |vauthors=Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ | title = DRAGON, a bone morphogenetic protein co-receptor | journal = J. Biol. Chem. | volume = 280 | issue = 14 | pages = 14122–9 |date=April 2005 | pmid = 15671031 | doi = 10.1074/jbc.M410034200 | url = | issn = }}
4. ^{{cite journal |vauthors=Severyn CJ, Shinde U, Rotwein P | title = Molecular biology, genetics and biochemistry of the repulsive guidance molecule family | journal = Biochem. J. | volume = 422 | issue = 3 | pages = 393–403 |date=September 2009 | pmid = 19698085 | doi = 10.1042/BJ20090978 | url = | issn = | pmc = 4242795 }}
5. ^{{cite journal |vauthors=Li J, Ye L, Sanders AJ, Jiang WG | title = Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling | journal = J Cell Biochem | volume = 113| issue = 7| pages = 2523–31|date=March 2012 | pmid = 22415859 | doi = 10.1002/jcb.24128 }}
6. ^{{cite journal |vauthors=Li J, Ye L, Kynaston HG, Jiang WG | title = Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells | journal = Int. J. Oncol. | volume = 40 | issue = 2 | pages = 544–50 |date=February 2012 | pmid = 22076499 | doi = 10.3892/ijo.2011.1251 }}
7. ^{{cite journal |vauthors=Li J, Ye L, Mansel RE, Jiang WG | title = Potential prognostic value of repulsive guidance molecules in breast cancer | journal = Anticancer Res. | volume = 31 | issue = 5 | pages = 1703–11 |date=May 2011 | pmid = 21617229 | doi = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
  • {{cite journal |vauthors=Samad TA, Srinivasan A, Karchewski LA, etal |title=DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. |journal=J. Neurosci. |volume=24 |issue= 8 |pages= 2027–36 |year= 2004 |pmid= 14985445 |doi= 10.1523/JNEUROSCI.4115-03.2004 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
{{refend}}{{NLM content}}

2 : Genes on human chromosome 5|Receptors
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