| 词条 | Reticular pigmented anomaly of the flexures |
| 释义 |
| name = Reticular pigmented anomaly of the flexures | synonyms = | image = | alt = | caption = | pronounce = | field = dermatology | geneReviewsID = | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Reticular pigmented anomaly of the flexures (also known as "dark dot disease", and "Dowling–Degos' disease") is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.[1]{{rp|856}} It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.[2] Dark dot disease is associated with KRT5.[3] See also
References1. ^James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. {{ISBN|0-7216-2921-0}}. 2. ^{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages= |isbn=978-1-4160-2999-1 |oclc= |doi= |accessdate=}} 3. ^{{cite journal |vauthors=Betz RC, Planko L, Eigelshoven S, etal |title=Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease |journal=Am. J. Hum. Genet. |volume=78 |issue=3 |pages=510–9 |date=March 2006 |pmid=16465624 |pmc=1380294 |doi=10.1086/500850 |url=http://linkinghub.elsevier.com/retrieve/pii/S0002-9297(07)62390-8}} External links{{Medical resources| DiseasesDB = | ICD10 = | ICD9 = | ICDO = | OMIM = 179850 | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = | GeneReviewsName = }}{{Cytoskeletal defects}}{{Cutaneous-condition-stub}} 1 : Disturbances of human pigmentation |
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