RF3 can refer to:

• Guerrilla, the third in a game franchise
• RF3, a candidate phylum of bacteria

• Ed Jenkins (U.S. politician)
• Ed John Belfour
• Ed Johnson
• Ed Johnson (American football)
• Ed Johnson (broadcaster)
• Ed Johnstone
• Ed Jones (football player)
• Ed Jones (US politician)
• Ed Joyce (journalist)
• Ed Jurak
• Ed Justice
• EDK
• Ed Kagin
• Ed Kahn
• Ed Karger
• Ed Karst
• Ed Kastelic
• Ed Kavalee
• Ed Kawal
• Ed Kea
• Ed Kealty
• Ed Keating
• Ed Kelly
• Ed Kennedy (outfielder)
• Ed Kenney