| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.[2]
}}InteractionsRGS12 has been shown to interact with GNAI1[3] and GNAI3.[3] References1. ^{{cite journal |vauthors=Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP | title = GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain | journal = J Biol Chem | volume = 273 | issue = 28 | pages = 17749–55 |date=August 1998 | pmid = 9651375 | pmc = | doi =10.1074/jbc.273.28.17749 }}
2. ^1 {{cite web | title = Entrez Gene: RGS12 regulator of G-protein signalling 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6002| accessdate = }}
3. ^1 {{cite journal |last=Kimple |first=R J |authorlink= |author2=De Vries L |author3=Tronchère H |author4=Behe C I |author5=Morris R A |author6=Gist Farquhar M |author7=Siderovski D P |date=August 2001 |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity |journal=J. Biol. Chem. |volume=276 |issue=31 |pages=29275–81 | issn = 0021-9258| pmid = 11387333 |doi = 10.1074/jbc.M103208200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{Refbegin | 2}}- {{cite journal |vauthors=Frohme M, Scharm B, Delius H, etal |title=Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue. |journal=Ann. N. Y. Acad. Sci. |volume=910 |issue= 1|pages= 85–104; discussion 104–5 |year= 2000 |pmid= 10911908 |doi=10.1111/j.1749-6632.2000.tb06703.x |bibcode=2000NYASA.910...85F }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal |vauthors=Snow BE, Antonio L, Suggs S, etal |title=Molecular cloning and expression analysis of rat Rgs12 and Rgs14. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 3 |pages= 770–7 |year= 1997 |pmid= 9168931 |doi= 10.1006/bbrc.1997.6537 }}
- {{cite journal |vauthors=Chatterjee TK, Fisher RA |title=Novel alternative splicing and nuclear localization of human RGS12 gene products. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29660–71 |year= 2000 |pmid= 10869340 |doi= 10.1074/jbc.M000330200 }}
- {{cite journal |vauthors=Schiff ML, Siderovski DP, Jordan JD, etal |title=Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. |journal=Nature |volume=408 |issue= 6813 |pages= 723–7 |year= 2001 |pmid= 11130074 |doi= 10.1038/35047093 }}
- {{cite journal |vauthors=Kimple RJ, De Vries L, Tronchère H, etal |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29275–81 |year= 2001 |pmid= 11387333 |doi= 10.1074/jbc.M103208200 }}
- {{cite book |vauthors=Snow BE, Brothers GM, Siderovski DP |title=Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain. |journal=Meth. Enzymol. |volume=344 |issue= |pages= 740–61 |year= 2002 |pmid= 11771424 |doi=10.1016/S0076-6879(02)44752-0 |series=Methods in Enzymology |isbn=9780121822453 }}
- {{cite journal |vauthors=Sierra DA, Gilbert DJ, Householder D, etal |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693 }}
- {{cite journal |vauthors=Chatterjee TK, Fisher RA |title=RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression. |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4334–45 |year= 2002 |pmid= 12024043 |doi=10.1128/MCB.22.12.4334-4345.2002 | pmc=133853 }}
- {{cite journal |vauthors=Potocnik U, Glavac D, Ravnik-Glavac M |title=Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability. |journal=Genes Chromosomes Cancer |volume=36 |issue= 1 |pages= 48–56 |year= 2003 |pmid= 12461749 |doi= 10.1002/gcc.10141 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
- {{cite journal |vauthors=Yang S, Li YP |title=RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro. |journal=J. Bone Miner. Res. |volume=22 |issue= 1 |pages= 45–54 |year= 2007 |pmid= 17042716 |doi= 10.1359/jbmr.061007 |pmc=3559086}}
{{Refend}}{{Gene-4-stub}} |