“Rhamnulokinase”的意思、由来-开放百科全书

词条

Rhamnulokinase

释义

Structural studies
References

{{enzyme
| Name = rhamnulokinase
| EC_number = 2.7.1.5
| CAS_number = 9030-52-8
| IUBMB_EC_number = 2/7/1/5
| GO_code = 0008993
| image =
| width =
| caption =
}}

In enzymology, a rhamnulokinase ({{EC number|2.7.1.5}}) is an enzyme that catalyzes the chemical reaction

ATP + L-rhamnulose ADP + L-rhamnulose 1-phosphate

Thus, the two substrates of this enzyme are ATP and L-rhamnulose, whereas its two products are ADP and L-rhamnulose 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:L-rhamnulose 1-phosphotransferase. Other names in common use include RhuK, rhamnulokinase (phosphorylating), L-rhamnulokinase, L-rhamnulose kinase, and rhamnulose kinase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes by Grueninger and Schulz with PDB accession codes {{PDB link|2CGJ}}, {{PDB link|2CGK}}, {{PDB link|2CGL}}, and {{PDB link|2UYT}}.

References

{{cite journal | vauthors = Wilson DM, Ajl S | title = Metabolism of L-rhamnose by Escherichia coli. II. The phosphorylation of L-rhamnulose | journal = Journal of Bacteriology | volume = 73 | issue = 3 | pages = 415–20 | date = March 1957 | pmid = 13416205 | pmc = 289814 }}
D.Grueninger and G.E.Schulz (2006). Structure and reaction mechanism of L-rhamnulose kinase from Escherichia coli.. J. Mol. Biol., 359, 787-797.
D.Grueninger and G.E.Schulz (2007). Substrate spectrum of L-rhamnulose kinase related to models derived from two ternary complex structures.. FEBS Lett, 581, 3127-3130.

2 : EC 2.7.1|Enzymes of known structure

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