| 释义 |
- References
- Further reading
{{Infobox_gene}}RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans.[1] RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT3 receptor and nicotinic acetylcholine receptors,[2][3] particularly the homomeric α7 nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.[4] References 1. ^{{cite journal | vauthors = Nguyen M, Alfonso A, Johnson CD, Rand JB | title = Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase | journal = Genetics | volume = 140 | issue = 2 | pages = 527–35 |date=Jun 1995 | pmid = 7498734 | pmc = 1206632| doi = }}
2. ^{{cite journal | vauthors = Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M | title = Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression | journal = J Biol Chem | volume = 278 | issue = 36 | pages = 34411–7 |date=Sep 2003 | pmid = 12821669 | pmc = | doi = 10.1074/jbc.M300170200 }}
3. ^{{cite web | title = Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79608| accessdate = }}
4. ^{{cite journal |vauthors=Williams ME, Burton B, Urrutia A, etal |title=Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1257–63 |year= 2005 |pmid= 15504725 |doi= 10.1074/jbc.M410039200 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Cheng A, Bollan KA, Greenwood SM, etal |title=Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition. |journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26158–66 |year= 2007 |pmid= 17609200 |doi= 10.1074/jbc.M703899200 }}
- {{cite journal |vauthors=Castillo M, Mulet J, Gutiérrez LM, etal |title=Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. |journal=J. Mol. Neurosci. |volume=30 |issue= 1–2 |pages= 153–6 |year= 2007 |pmid= 17192664 |doi= 10.1385/JMN:30:1:153 }}
- {{cite journal |vauthors=Lansdell SJ, Gee VJ, Harkness PC, etal |title=RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells |journal=Mol. Pharmacol. |volume=68 |issue= 5 |pages= 1431–8 |year= 2005 |pmid= 16120769 |doi= 10.1124/mol.105.017459 }}
- {{cite journal |vauthors=Castillo M, Mulet J, Gutiérrez LM, etal |title=Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 27062–8 |year= 2005 |pmid= 15927954 |doi= 10.1074/jbc.M503746200 }}
- {{cite journal | vauthors=Cheng A, McDonald NA, Connolly CN |title=Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3 |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 22502–7 |year= 2005 |pmid= 15809299 |doi= 10.1074/jbc.M414341200 }}
- {{cite journal |vauthors=Bennett HM, Lees K, etal |title=Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes |journal=J. Neurochem. |volume=123 |issue= 6 |pages= 911–8 |year= 2012 |pmid= 22970690 |doi= 10.1111/jnc.12013 |pmc=3549563}}
- {{cite journal |vauthors=Koperniak TM, Garg BK, etal |title=Cell-specific effects on surface α7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein |journal=J. Neurochem. |volume=124 |issue= 3 |pages= 300–9 |year= 2013 |pmid= 23157401 |doi= 10.1111/jnc.12095 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
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