| 释义 |
- References
- Further reading
{{Infobox_gene}}Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.[1][2][3]RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.[4] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.[5] References 1. ^{{cite journal | vauthors = Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T | title = Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint | journal = Genes & Development | volume = 18 | issue = 17 | pages = 2108–19 | date = September 2004 | pmid = 15342490 | pmc = 515289 | doi = 10.1101/gad.1216004 }}
2. ^{{cite journal | vauthors = Adams IR, McLaren A | title = Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells | journal = Developmental Dynamics | volume = 229 | issue = 4 | pages = 733–44 | date = April 2004 | pmid = 15042697 | pmc = | doi = 10.1002/dvdy.10471 }}
3. ^{{cite web | title = Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55183| accessdate = }}
4. ^{{cite journal | vauthors = Ribeyre C, Shore D | title = Anticheckpoint pathways at telomeres in yeast | journal = Nature Structural & Molecular Biology | volume = 19 | issue = 3 | pages = 307–13 | year = 2012 | pmid = 22343724 | doi = 10.1038/nsmb.2225 }}
5. ^{{cite journal | vauthors = Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA | title = Serial interactome capture of the human cell nucleus | journal = Nature Communications | volume = 7 | pages = 11212 | date = 2016-01-01 | pmid = 27040163 | doi = 10.1038/ncomms11212 | pmc=4822031}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = April 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
- {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = April 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
- {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
- {{cite journal | vauthors = Xu L, Blackburn EH | title = Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules | journal = The Journal of Cell Biology | volume = 167 | issue = 5 | pages = 819–30 | date = December 2004 | pmid = 15583028 | pmc = 2172464 | doi = 10.1083/jcb.200408181 }}
- {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = October 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
{{refend}}{{gene-2-stub}} 3 : Telomeres|Telomere-related genes|Telomere-related proteins |