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词条 Rnd1
释义

  1. Interactions

  2. References

  3. Further reading

{{Infobox_gene}}Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1] It is encoded by the gene RND1.[2]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][2]

Interactions

Rnd1 has been shown to interact with GRB7,[3] PLXNB1,[4] PDE6D,[5][6] ARHGAP5[7] and UBXD5.[8]

References

1. ^{{cite journal | vauthors = Ridley AJ | title = Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking | journal = Trends in Cell Biology | volume = 16 | issue = 10 | pages = 522–9 | date = Oct 2006 | pmid = 16949823 | doi = 10.1016/j.tcb.2006.08.006 }}
2. ^1 {{cite web | title = Entrez Gene: RND1 Rho family GTPase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27289| accessdate = }}
3. ^{{cite journal | vauthors = Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J | title = Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family | journal = FEBS Letters | volume = 467 | issue = 1 | pages = 91–6 | date = Feb 2000 | pmid = 10664463 | doi = 10.1016/S0014-5793(99)01530-6 }}
4. ^{{cite journal | vauthors = Oinuma I, Katoh H, Harada A, Negishi M | title = Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 25671–7 | date = Jul 2003 | pmid = 12730235 | doi = 10.1074/jbc.M303047200 }}
5. ^{{cite journal | vauthors = Nancy V, Callebaut I, El Marjou A, de Gunzburg J | title = The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 15076–84 | date = Apr 2002 | pmid = 11786539 | doi = 10.1074/jbc.M109983200 }}
6. ^{{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = The EMBO Journal | volume = 21 | issue = 9 | pages = 2095–106 | date = May 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}
7. ^{{cite journal | vauthors = Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH | title = Rnd proteins function as RhoA antagonists by activating p190 RhoGAP | journal = Current Biology | volume = 13 | issue = 13 | pages = 1106–15 | date = Jul 2003 | pmid = 12842009 | doi = 10.1016/S0960-9822(03)00418-4 }}
8. ^{{cite journal | vauthors = Katoh H, Harada A, Mori K, Negishi M | title = Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 2952–64 | date = May 2002 | pmid = 11940653 | pmc = 133765 | doi = 10.1128/MCB.22.9.2952-2964.2002 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P | title = A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion | journal = The Journal of Cell Biology | volume = 141 | issue = 1 | pages = 187–97 | date = Apr 1998 | pmid = 9531558 | pmc = 2132722 | doi = 10.1083/jcb.141.1.187 }}
  • {{cite journal | vauthors = Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J | title = Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family | journal = FEBS Letters | volume = 467 | issue = 1 | pages = 91–6 | date = Feb 2000 | pmid = 10664463 | doi = 10.1016/S0014-5793(99)01530-6 }}
  • {{cite journal | vauthors = Aoki J, Katoh H, Mori K, Negishi M | title = Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells | journal = Biochemical and Biophysical Research Communications | volume = 278 | issue = 3 | pages = 604–8 | date = Nov 2000 | pmid = 11095956 | doi = 10.1006/bbrc.2000.3842 }}
  • {{cite journal | vauthors = Rohm B, Rahim B, Kleiber B, Hovatta I, Püschel AW | title = The semaphorin 3A receptor may directly regulate the activity of small GTPases | journal = FEBS Letters | volume = 486 | issue = 1 | pages = 68–72 | date = Dec 2000 | pmid = 11108845 | doi = 10.1016/S0014-5793(00)02240-7 }}
  • {{cite journal | vauthors = Nancy V, Callebaut I, El Marjou A, de Gunzburg J | title = The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 15076–84 | date = Apr 2002 | pmid = 11786539 | doi = 10.1074/jbc.M109983200 }}
  • {{cite journal | vauthors = Katoh H, Harada A, Mori K, Negishi M | title = Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 2952–64 | date = May 2002 | pmid = 11940653 | pmc = 133765 | doi = 10.1128/MCB.22.9.2952-2964.2002 }}
  • {{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = The EMBO Journal | volume = 21 | issue = 9 | pages = 2095–106 | date = May 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}
  • {{cite journal | vauthors = Oinuma I, Katoh H, Harada A, Negishi M | title = Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 25671–7 | date = Jul 2003 | pmid = 12730235 | doi = 10.1074/jbc.M303047200 }}
  • {{cite journal | vauthors = Oinuma I, Ishikawa Y, Katoh H, Negishi M | title = The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras | journal = Science | volume = 305 | issue = 5685 | pages = 862–5 | date = Aug 2004 | pmid = 15297673 | doi = 10.1126/science.1097545 }}
  • {{cite journal | vauthors = Harada A, Katoh H, Negishi M | title = Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells | journal = The Journal of Biological Chemistry | volume = 280 | issue = 18 | pages = 18418–24 | date = May 2005 | pmid = 15738000 | doi = 10.1074/jbc.M411356200 }}
  • {{cite journal | vauthors = Kim YS, Hori M, Yasuda K, Ozaki H | title = Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria | journal = Comparative Biochemistry and Physiology A | volume = 142 | issue = 4 | pages = 410–5 | date = Dec 2005 | pmid = 16311049 | doi = 10.1016/j.cbpa.2005.08.028 }}
{{refend}}{{PDB Gallery|geneid=27289}}{{Rho family of GTPases}}{{gene-12-stub}}
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