“Rnd2”的意思、由来-开放百科全书

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]^[3]

This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.

Clinical significance

The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.^[2]

Interactions

References

1. ^{{cite journal | vauthors = Ridley AJ | title = Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking | journal = Trends Cell Biol | volume = 16 | issue = 10 | pages = 522–9 | year = 2006 | pmid = 16949823 | doi = 10.1016/j.tcb.2006.08.006 | issn = 0962-8924 }}
2. ^¹{{cite web | title = Entrez Gene: RND2 Rho family GTPase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8153| accessdate = }}
3. ^{{cite web | title = Entrez Gene: RND1 Rho family GTPase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27289| accessdate = }}
4. ^{{cite journal | vauthors = Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH | title = Rnd proteins function as RhoA antagonists by activating p190 RhoGAP | journal = Curr. Biol. | volume = 13 | issue = 13 | pages = 1106–15 | date = Jul 2003 | pmid = 12842009 | doi = 10.1016/s0960-9822(03)00418-4}}
5. ^{{cite journal | vauthors = Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, Chardin P, Gacon G | title = Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells | journal = Biochem. J. | volume = 372 | issue = Pt 1 | pages = 105–12 | date = May 2003 | pmid = 12590651 | pmc = 1223378 | doi = 10.1042/BJ20021652 }}
6. ^{{cite journal | vauthors = Katoh H, Harada A, Mori K, Negishi M | title = Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers | journal = Mol. Cell. Biol. | volume = 22 | issue = 9 | pages = 2952–64 | date = May 2002 | pmid = 11940653 | pmc = 133765 | doi = 10.1128/mcb.22.9.2952-2964.2002}}

Further reading

{{cite journal | vauthors = Chardin P | title = Small GTP-binding proteins of the ras family: a conserved functional mechanism? | journal = Cancer Cells | volume = 3 | issue = 4 | pages = 117–26 | year = 1991 | pmid = 1909153 | doi = }}

{{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}

{{cite journal | vauthors = Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC | title = Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1 | journal = Genome Res. | volume = 6 | issue = 11 | pages = 1029–49 | year = 1997 | pmid = 8938427 | doi = 10.1101/gr.6.11.1029 }}

{{cite journal | vauthors = Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P | title = A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion | journal = J. Cell Biol. | volume = 141 | issue = 1 | pages = 187–97 | year = 1998 | pmid = 9531558 | pmc = 2132722 | doi = 10.1083/jcb.141.1.187 }}

{{cite journal | vauthors = Tanaka H, Fujita H, Katoh H, Mori K, Negishi M | title = Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2 | journal = Biochem. J. | volume = 365 | issue = Pt 2 | pages = 349–53 | year = 2002 | pmid = 11931639 | pmc = 1222680 | doi = 10.1042/BJ20020062 }}

{{cite journal | vauthors = Katoh H, Harada A, Mori K, Negishi M | title = Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers | journal = Mol. Cell. Biol. | volume = 22 | issue = 9 | pages = 2952–64 | year = 2002 | pmid = 11940653 | pmc = 133765 | doi = 10.1128/MCB.22.9.2952-2964.2002 }}

{{cite journal | vauthors = Fujita H, Katoh H, Ishikawa Y, Mori K, Negishi M | title = Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45428–34 | year = 2003 | pmid = 12244061 | doi = 10.1074/jbc.M208090200 }}

{{cite journal | vauthors = Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, Chardin P, Gacon G | title = Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells | journal = Biochem. J. | volume = 372 | issue = Pt 1 | pages = 105–12 | year = 2003 | pmid = 12590651 | pmc = 1223378 | doi = 10.1042/BJ20021652 }}

{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

{{cite journal | vauthors = Kim YS, Hori M, Yasuda K, Ozaki H | title = Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria | journal = Comp. Biochem. Physiol., Part a Mol. Integr. Physiol. | volume = 142 | issue = 4 | pages = 410–5 | year = 2006 | pmid = 16311049 | doi = 10.1016/j.cbpa.2005.08.028 }}

{{cite journal | vauthors = Tanaka H, Katoh H, Negishi M | title = Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity | journal = J. Biol. Chem. | volume = 281 | issue = 15 | pages = 10355–64 | year = 2006 | pmid = 16481321 | doi = 10.1074/jbc.M511314200 }}

Function

Clinical significance

Interactions

References

Further reading