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词条 RNF10
释义

  1. Function

  2. References

  3. Further reading

{{Infobox_gene}}RING finger protein 10 is a protein that in humans is encoded by the RNF10 gene.[1]

Function

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known.[1]

==Model organisms==

Model organisms have been used in the study of RNF10 function. A conditional knockout mouse line, called Rnf10tm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty two tests were carried out on mutant mice and five significant abnormalities were observed.[8] Homozygous mutant animals displayed increased chromosomal stability in a micronucleus test. Females also had increased body weight, an increased amount of total body fat and an abnormal complete blood count. Males additionally displayed an increase in eating behavior.[8]

References

1. ^1 {{cite web | title = Entrez Gene: RNF10 ring finger protein 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9921| accessdate = }}
2. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MCJK/weight-curves/ |title=Body weight data for Rnf10 |publisher=Wellcome Trust Sanger Institute}}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MCJK/indirect-calorimetry/ |title=Indirect calorimetry data for Rnf10 |publisher=Wellcome Trust Sanger Institute}}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MCJK/body-composition-dexa/ |title=DEXA data for Rnf10 |publisher=Wellcome Trust Sanger Institute}}
5. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MCJK/haematology-cbc/ |title=Haematology data for Rnf10 |publisher=Wellcome Trust Sanger Institute}}
6. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MCJK/salmonella-challenge/ |title=Salmonella infection data for Rnf10 |publisher=Wellcome Trust Sanger Institute}}
7. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MCJK/citrobacter-challenge/ |title=Citrobacter infection data for Rnf10 |publisher=Wellcome Trust Sanger Institute}}
8. ^1 2 3 {{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages = 925–7 }}
9. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
10. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Rnf10 |title=International Knockout Mouse Consortium}}
11. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4362564 |title=Mouse Genome Informatics}}
12. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
13. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
14. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
15. ^{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
  • {{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Research | volume = 3 | issue = 5 | pages = 321–9, 341-54 | date = Oct 1996 | pmid = 9039502 | doi = 10.1093/dnares/3.5.321 }}
  • {{cite journal | vauthors = Seki N, Hattori A, Sugano S, Muramatsu M, Saito T | title = cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein | journal = Journal of Human Genetics | volume = 45 | issue = 1 | pages = 38–42 | year = 2000 | pmid = 10697961 | doi = 10.1007/s100380050007 }}
  • {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
  • {{cite journal | vauthors = Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT | title = Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10 | journal = Molecular and Cellular Biochemistry | volume = 275 | issue = 1-2 | pages = 75–84 | date = Jul 2005 | pmid = 16335786 | doi = 10.1007/s11010-005-0823-3 }}
  • {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
{{refend}}

2 : Genes mutated in mice|RING finger proteins
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