| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.[1][2] Function The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[2] Interactions RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7[3] and Mothers against decapentaplegic homolog 3.[3][4] References 1. ^{{cite journal | vauthors = Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D | title = Induction of the mammalian node requires Arkadia function in the extraembryonic lineages | journal = Nature | volume = 410 | issue = 6830 | pages = 825–30 | date = Apr 2001 | pmid = 11298452 | pmc = | doi = 10.1038/35071095 }}
2. ^1 {{cite web | title = Entrez Gene: RNF111 ring finger protein 111| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54778| accessdate = }}
3. ^1 {{cite journal | vauthors = Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K | title = Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 | journal = The EMBO Journal | volume = 22 | issue = 24 | pages = 6458–70 | date = Dec 2003 | pmid = 14657019 | pmc = 291827 | doi = 10.1093/emboj/cdg632 }}
4. ^{{cite journal | vauthors = Yuzawa H, Koinuma D, Maeda S, Yamamoto K, Miyazawa K, Imamura T | title = Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts | journal = Bone | volume = 44 | issue = 1 | pages = 53–60 | date = Jan 2009 | pmid = 18950738 | doi = 10.1016/j.bone.2008.09.013 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Patten I, Placzek M | title = Vertebrate development: Et in Arkadia | journal = Current Biology | volume = 11 | issue = 15 | pages = R616-9 | date = Aug 2001 | pmid = 11516970 | doi = 10.1016/S0960-9822(01)00367-0 }}
- {{cite journal | vauthors = Niederländer C, Walsh JJ, Episkopou V, Jones CM | title = Arkadia enhances nodal-related signalling to induce mesendoderm | journal = Nature | volume = 410 | issue = 6830 | pages = 830–4 | date = Apr 2001 | pmid = 11298453 | doi = 10.1038/35071103 }}
- {{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 26 | pages = 16899–903 | date = Dec 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}
- {{cite journal | vauthors = Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K | title = Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 | journal = The EMBO Journal | volume = 22 | issue = 24 | pages = 6458–70 | date = Dec 2003 | pmid = 14657019 | pmc = 291827 | doi = 10.1093/emboj/cdg632 }}
- {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
- {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
- {{cite journal | vauthors = Liu W, Rui H, Wang J, Lin S, He Y, Chen M, Li Q, Ye Z, Zhang S, Chan SC, Chen YG, Han J, Lin SC | title = Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia | journal = The EMBO Journal | volume = 25 | issue = 8 | pages = 1646–58 | date = Apr 2006 | pmid = 16601693 | pmc = 1440825 | doi = 10.1038/sj.emboj.7601057 }}
- {{cite journal | vauthors = Nagano Y, Mavrakis KJ, Lee KL, Fujii T, Koinuma D, Sase H, Yuki K, Isogaya K, Saitoh M, Imamura T, Episkopou V, Miyazono K, Miyazawa K | title = Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling | journal = The Journal of Biological Chemistry | volume = 282 | issue = 28 | pages = 20492–501 | date = Jul 2007 | pmid = 17510063 | doi = 10.1074/jbc.M701294200 }}
- {{cite journal | vauthors = Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS | title = Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation | journal = Molecular and Cellular Biology | volume = 27 | issue = 17 | pages = 6068–83 | date = Sep 2007 | pmid = 17591695 | pmc = 1952153 | doi = 10.1128/MCB.00664-07 }}
{{refend}}{{gene-15-stub}} 1 : RING finger proteins |