| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.[1][2] Function The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.[2] Functions in female mice as a regulator of X chromosome inactivation . Interactions RNF12 has been shown to interact with Estrogen receptor alpha.[3] References 1. ^{{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = Int. J. Cancer | volume = 83 | issue = 4 | pages = 456–64 | date = Nov 1999 | pmid = 10508479 | pmc = | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
2. ^1 {{cite web | title = Entrez Gene: RNF12 ring finger protein 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51132| accessdate = }}
3. ^{{cite journal | vauthors = Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I | title = Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer | journal = Cancer Res. | volume = 69 | issue = 1 | pages = 128–36 | date = Jan 2009 | pmid = 19117995 | pmc = 2713826 | doi = 10.1158/0008-5472.CAN-08-1630 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
- {{cite journal | vauthors = Hiratani I, Yamamoto N, Mochizuki T, Ohmori SY, Taira M | title = Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions | journal = Development | volume = 130 | issue = 17 | pages = 4161–75 | year = 2003 | pmid = 12874135 | doi = 10.1242/dev.00621 }}
- {{cite journal | vauthors = Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I | title = Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors | journal = Nature | volume = 416 | issue = 6876 | pages = 99–103 | year = 2002 | pmid = 11882901 | doi = 10.1038/416099a }}
- {{cite journal | vauthors = Ostendorff HP, Bossenz M, Mincheva A, Copeland NG, Gilbert DJ, Jenkins NA, Lichter P, Bach I | title = Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors | journal = Genomics | volume = 69 | issue = 1 | pages = 120–30 | year = 2000 | pmid = 11013082 | doi = 10.1006/geno.2000.6311 }}
- {{cite journal | vauthors = Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG | title = RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex | journal = Nat. Genet. | volume = 22 | issue = 4 | pages = 394–9 | year = 1999 | pmid = 10431247 | doi = 10.1038/11970 }}
- {{cite journal | vauthors = Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I | title = Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice | journal = Nature | volume = 467 | issue = 7318 | pages = 977–81 | year = 2010 | pmid = 20962847 | doi = 10.1038/nature09457 | pmc=2967734}}
- {{cite journal | vauthors = Jiao B, Taniguchi-Ishigaki N, Güngör C, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA, Bach I | title = Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling | journal = Mol Biol Cell | volume = 24 | issue = 19 | pages = 3085–96 | year = 2013 | pmid = 23904271 | doi = 10.1091/mbc.E13-05-0239 | pmc=3784382}}
{{refend}}{{gene-X-stub}} 1 : RING finger proteins |