词条 | RNF40 |
释义 |
FunctionThe protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.[5] InteractionsRNF40 has been shown to interact with STX1A.[3] References1. ^{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 3 | pages = 169–76 | date = Dec 1998 | pmid = 9734811 | pmc = | doi = 10.1093/dnares/5.3.169 }} 2. ^{{cite journal | vauthors = Wen H, Ao S | title = RBP95, a novel leucine zipper protein, binds to the retinoblastoma protein | journal = Biochem. Biophys. Res. Commun. | volume = 275 | issue = 1 | pages = 141–8 | date = Sep 2000 | pmid = 10944455 | pmc = | doi = 10.1006/bbrc.2000.3242 }} 3. ^1 {{cite journal | vauthors = Chin LS, Vavalle JP, Li L | title = Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation | journal = J. Biol. Chem. | volume = 277 | issue = 38 | pages = 35071–9 | date = Sep 2002 | pmid = 12121982 | pmc = | doi = 10.1074/jbc.M203300200 }} 4. ^{{cite web | title = Entrez Gene: RNF40 ring finger protein 40| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9810| accessdate = }} 5. ^{{cite web | title = Entrez Gene: RNF40 ring finger protein 40| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9810| accessdate = }} Further reading{{refbegin | 2}}
1 : RING finger proteins |
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