| 释义 |
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.[1][2][3]The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3] InteractionsRNF7 has been shown to interact with CSNK2B.[4] See alsoReferences1. ^{{cite journal |vauthors=Duan H, Wang Y, Aviram M, Swaroop M, Loo JA, Bian J, Tian Y, Mueller T, Bisgaier CL, Sun Y | title = SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents | journal = Mol Cell Biol | volume = 19 | issue = 4 | pages = 3145–55 |date=April 1999 | pmid = 10082581 | pmc = 84108 | doi = }}
2. ^{{cite journal |vauthors=Ohta T, Michel JJ, Schottelius AJ, Xiong Y | title = ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | journal = Mol Cell | volume = 3 | issue = 4 | pages = 535–41 |date=May 1999 | pmid = 10230407 | pmc = | doi =10.1016/S1097-2765(00)80482-7 }}
3. ^1 {{cite web | title = Entrez Gene: RNF7 ring finger protein 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9616| accessdate = }}
4. ^{{cite journal |last=Ahn |first=B H |authorlink= |author2=Kim T H |author3=Bae Y S |date=October 2001 |title=Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins |journal=Mol. Cells |volume=12 |issue=2 |pages=158–63 |publisher= |location = Korea (South)| issn = 1016-8478| pmid = 11710515 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{Refbegin | 2}}- {{cite journal |vauthors=Tan P, Fuchs SY, Chen A, etal |title=Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha |journal=Mol. Cell |volume=3 |issue= 4 |pages= 527–33 |year= 1999 |pmid= 10230406 |doi=10.1016/S1097-2765(00)80481-5 }}
- {{cite journal |vauthors=Swaroop M, Bian J, Aviram M, etal |title=Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein |journal=Free Radic. Biol. Med. |volume=27 |issue= 1–2 |pages= 193–202 |year= 1999 |pmid= 10443936 |doi=10.1016/S0891-5849(99)00078-7 }}
- {{cite journal | author=Sun Y |title=Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection |journal=Carcinogenesis |volume=20 |issue= 10 |pages= 1899–903 |year= 1999 |pmid= 10506102 |doi=10.1093/carcin/20.10.1899 }}
- {{cite journal |vauthors=Son MY, Park JW, Kim YS, etal |title=Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 3 |pages= 743–8 |year= 1999 |pmid= 10512750 |doi= 10.1006/bbrc.1999.1460 }}
- {{cite journal |vauthors=Chen A, Wu K, Fuchs SY, etal |title=The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15432–9 |year= 2000 |pmid= 10748083 |doi= 10.1074/jbc.M907300199 }}
- {{cite journal |vauthors=Swaroop M, Wang Y, Miller P, etal |title=Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation |journal=Oncogene |volume=19 |issue= 24 |pages= 2855–66 |year= 2000 |pmid= 10851089 |doi= 10.1038/sj.onc.1203635 }}
- {{cite journal |vauthors=Furukawa M, Zhang Y, McCarville J, etal |title=The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1 |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8185–97 |year= 2000 |pmid= 11027288 |doi=10.1128/MCB.20.21.8185-8197.2000 | pmc=86428 }}
- {{cite journal |vauthors=Duan H, Tsvetkov LM, Liu Y, etal |title=Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation |journal=Mol. Carcinog. |volume=30 |issue= 1 |pages= 37–46 |year= 2001 |pmid= 11255262 |doi=10.1002/1098-2744(200101)30:1<37::AID-MC1011>3.0.CO;2-7 }}
- {{cite journal |vauthors=Swaroop M, Gosink M, Sun Y |title=SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes |journal=DNA Cell Biol. |volume=20 |issue= 7 |pages= 425–34 |year= 2001 |pmid= 11506706 |doi= 10.1089/104454901750361488 |url=https://deepblue.lib.umich.edu/bitstream/2027.42/63441/1/104454901750361488.pdf }}
- {{cite journal |vauthors=Ahn BH, Kim TH, Bae YS |title=Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins |journal=Mol. Cells |volume=12 |issue= 2 |pages= 158–63 |year= 2002 |pmid= 11710515 |doi= }}
- {{cite journal |vauthors=Furukawa M, Ohta T, Xiong Y |title=Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15758–65 |year= 2002 |pmid= 11861641 |doi= 10.1074/jbc.M108565200 }}
- {{cite journal |vauthors=Kim SY, Bae YS, Park JW |title=Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein |journal=Free Radic. Res. |volume=36 |issue= 1 |pages= 73–8 |year= 2002 |pmid= 11999705 |doi=10.1080/10715760210164 }}
- {{cite journal |vauthors=Kim YS, Ha KS, Kim YH, Bae YS |title=The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 6 |pages= 629–36 |year= 2003 |pmid= 12470599 |doi= 10.5483/bmbrep.2002.35.6.629}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Kim SY, Lee JH, Yang ES, etal |title=Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 671–4 |year= 2003 |pmid= 12565832 |doi=10.1016/S0006-291X(03)00018-4 }}
- {{cite journal |vauthors=Kim YS, Lee JY, Son MY, etal |title=Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1 |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28462–9 |year= 2003 |pmid= 12748192 |doi= 10.1074/jbc.M302584200 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
{{Refend}} External links - {{MeshName|RNF7+protein,+human}}
{{Gene-3-stub}} 1 : RING finger proteins |