| 词条 | Ro60-0175 |
| 释义 |
| verifiedrevid = 405764492 | IUPAC_name = (S)-6-Chloro-5-fluoro-1H-indole-2-propanamine | image = Ro60-0175_structure.png | width = 240 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 274 | ATC_prefix = | ATC_suffix = | PubChem = 3045227 | ChemSpiderID = 2308002 | ChEBI = 142183 | C=11 | H=12 | Cl=1 | F=1 | N=2 | molecular_weight = 226.677 g/mol | smiles = C[C@@H](Cn1ccc2c1cc(c(c2)F)Cl)N | StdInChI = 1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1 | StdInChIKey = XJJZQXUGLLXTHO-ZETCQYMHSA-N | melting_point = | melting_high = |drug_name=|alt=|caption=|type=|MedlinePlus=|licence_EU=|licence_US=|DrugBank=}}Ro60-0175 is a drug developed by Hoffmann–La Roche, which has applications in scientific research.[1][2] It acts as a potent and selective agonist for both the 5-HT2B and 5-HT2C serotonin receptor subtypes, with good selectivity over the closely related 5-HT2A subtype, and little or no affinity at other receptors.[3][4] See also
References1. ^Quarta D, Naylor CG, Stolerman IP. The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination. Psychopharmacology. 2007 Aug;193(3):391-402. {{PMID|17473916}} {{Serotonergics}}{{nervous-system-drug-stub}}2. ^Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008 May;33(6):1402-12. {{PMID|17653111}} 3. ^Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. British Journal of Pharmacology. 1999 Sep;128(1):13-20. {{DOI|10.1038/sj.bjp.0702751}} {{PMID|10498829}} 4. ^Damjanoska KJ, Muma NA, Zhang Y, D'Souza DN, Garcia F, Carrasco GA, Kindel GH, Haskins KA, Shankaran M, Petersen BR, Van De Kar LD. Neuroendocrine evidence that (S)-2-(6-chloro-5-fluoro-indol-1-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist. Journal of Pharmacology and Experimental Therapeutics. 2003 Mar;304(3):1209-16. {{PMID|12604698}} 6 : 5-HT2B agonists|Serotonin receptor agonists|Indoles|Chloroarenes|Fluoroarenes|Hoffmann-La Roche |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。