| 词条 | Robert Tjian |
| 释义 |
| name = Robert Tjian | image = | image_size = | alt = | caption = | birth_date = | birth_place = Hong Kong | death_date = | death_place = | residence = | citizenship = | nationality = | fields = | workplaces = University of California, Berkeley, HHMI | alma_mater = University of California, Berkeley, Harvard University, Cold Spring Harbor Laboratory | doctoral_advisor = Richard Losick | academic_advisors = Richard Losick, James D. Watson | doctoral_students = Brian David Dynlacht | notable_students = | known_for = | author_abbrev_bot = | author_abbrev_zoo = | influences = | influenced = | awards = {{no wrap|NAS Award in Molecular Biology {{small|(1991)}} Louisa Gross Horwitz Prize {{small|(1999)}} Alfred P. Sloan Jr. Prize {{small|(1999)}}}} | signature = | signature_alt = | footnotes = | spouse = }}Robert Tjian ({{zh|t=錢澤南|p=Qián Zénán}}; born 1949) is an Asian-American biochemist best known for his work on eukaryotic transcription. He is currently Professor of Biochemistry and Molecular Biology at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute (HHMI). On April 1, 2009, Tjian became the President of HHMI. On August 4, 2015, he announced that he would step down as President at the end of 2016.[1] BiographyTjian was born in Hong Kong in 1949. His father Tjian Tze-Ning (Qian Zining; 錢子寧), a native of Shaoxing, Zhejiang, was a famous capitalist in Shanghai and pioneer of China's modern paper industry. In April 1949, Tjian's family and business all moved to Hong Kong; in 1950 moved to São Paulo, Brazil; and later settled in New Jersey, the United States.[2] Tjian received a Bachelor of Arts degree from the University of California, Berkeley in 1971 and a Ph.D. degree from Harvard University in 1976. He was a postdoctoral fellow at Cold Spring Harbor Laboratory with James D. Watson for three years before returning to the University of California in 1979 when he was appointed Assistant Professor of Biochemistry.[3] In 2008, Tjian joined the Board of Directors of the Lasker Foundation. In 1978, Tjian found the first protein of a virus which can regulate gene expression in mammalian cells, the SV40 large T antigen. He showed that "activator" proteins, which previously had been shown to play crucial roles in regulating gene expression in simple organisms, also exist in higher organisms. He and his colleagues further discovered several gene-regulatory proteins. Tjian is also notable in drug-target studies and their applications. Tjian developed some highly efficient and sensitive techniques to detect cellular quantities such as proteins. In 1989, Tjian, together with two colleagues David Goeddel (father of MLB players Erik and Tyler Goeddel) and Steve McKnight, co-founded Tularik Inc., a biotechnology company based in South San Francisco, California. Tularik was acquired by Amgen for $1.3 billion in 2004.[4] Tjian is also a member of the USA Science and Engineering Festival's Advisory Board.[5] Awards and honors
External links
References1. ^http://www.hhmi.org/news/hhmi-president-robert-tjian-step-down, accessed January 16, 2016. {{Pfizer Award in Enzyme Chemistry}}{{Authority control}}{{DEFAULTSORT:Tjian, Robert}}2. ^Baidu Baike: Pioneer of China's Modern Paper Industry: Tjian Tze-Ning 3. ^ScienceWatch Archive: Robert Tjian Pioneers a Biochemical Path to Transcription Studies 4. ^{{cite web|url=http://www.amgen.com/media/media_pr_detail.jsp?year=2004&releaseID=509295|title=Amgen to Acquire Tularik for $1.3 Billion|date=2004-03-29|author=Amgen|publisher=Amgen}} 5. ^{{cite web |url=http://www.usasciencefestival.org/about/advisors |title=Archived copy |accessdate=2016-04-12 |deadurl=yes |archiveurl=https://web.archive.org/web/20100421005310/http://www.usasciencefestival.org/about/advisors/ |archivedate=2010-04-21 |df= }} retrieved 2010-07-05 6. ^[https://db1n.sinica.edu.tw/textdb/ioconas/02.php?func=22&_op=?ID:L035 院士基本資料: 錢澤南 (Basic information of Academician: Robert Tjian)] 7. ^Robert Tjian Named California Scientist of Year- by Robert Sanders 8. ^National Cancer Institute: MERIT Award Recipient: Robert Tjian, PhD 15 : 1949 births|Living people|American biochemists|American medical researchers|American nonprofit chief executives|Fellows of the American Academy of Arts and Sciences|Hong Kong emigrants to the United States|Howard Hughes Medical Investigators|Members of the United States National Academy of Sciences|University of California, Berkeley faculty|University of California, Berkeley alumni|Harvard Medical School alumni|American scientists of Chinese descent|Chinese biochemists|Hong Kong scientists |
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