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词条 RRM1
释义

  1. Interactive pathway map

  2. See also

  3. References

  4. Further reading

{{Infobox_gene}}Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.[3]
}}

Interactive pathway map

{{FluoropyrimidineActivity WP1601|highlight=RRM1}}

See also

  • Ribonucleotide reductase

References

1. ^{{cite journal |vauthors=Parker NJ, Begley CG, Fox RM | title = Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter | journal = Genomics | volume = 27 | issue = 2 | pages = 280–5 |date=Nov 1995 | pmid = 7557993 | pmc = | doi = 10.1006/geno.1995.1043 }}
2. ^{{cite web | title = Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6240| accessdate = }}
3. ^{{cite web | title = Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6240| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Pavloff N, Rivard D, Masson S, etal |title=Sequence analysis of the large and small subunits of human ribonucleotide reductase. |journal=DNA Seq. |volume=2 |issue= 4 |pages= 227–34 |year= 1992 |pmid= 1627826 |doi=10.3109/10425179209020807 }}
  • {{cite journal |vauthors=Byrne J, Smith P |title=Human polymorphic probe pE1.8 detects SacI polymorphism in the ribonucleotide reductase M1 subunit gene. |journal=Hum. Genet. |volume=87 |issue= 3 |pages= 376 |year= 1991 |pmid= 1677928 |doi=10.1007/BF00200924 }}
  • {{cite journal |vauthors=Parker NJ, Begley CG, Fox RM |title=Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes. |journal=Nucleic Acids Res. |volume=19 |issue= 13 |pages= 3741 |year= 1991 |pmid= 1840662 |doi=10.1093/nar/19.13.3741 | pmc=328406 }}
  • {{cite journal |vauthors=Mann GJ, Musgrove EA, Fox RM, Thelander L |title=Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation. |journal=Cancer Res. |volume=48 |issue= 18 |pages= 5151–6 |year= 1988 |pmid= 3044582 |doi= }}
  • {{cite journal |vauthors=Brissenden JE, Caras I, Thelander L, Francke U |title=The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse. |journal=Exp. Cell Res. |volume=174 |issue= 1 |pages= 302–8 |year= 1988 |pmid= 3275546 |doi=10.1016/0014-4827(88)90165-6 }}
  • {{cite journal |vauthors=Engström Y, Francke U |title=Assignment of the structural gene for subunit M1 of human ribonucleotide reductase to the short arm of chromosome 11. |journal=Exp. Cell Res. |volume=158 |issue= 2 |pages= 477–83 |year= 1985 |pmid= 3891388 |doi=10.1016/0014-4827(85)90470-7 }}
  • {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal |vauthors=Parker NJ, Begley CG, Fox RM |title=Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene |journal=Genomics |volume=19 |issue= 1 |pages= 91–6 |year= 1994 |pmid= 8188248 |doi= 10.1006/geno.1994.1017 }}
  • {{cite journal |vauthors=Byrne JA, Smith PJ |title=The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma |journal=Hum. Genet. |volume=91 |issue= 3 |pages= 275–7 |year= 1993 |pmid= 8386696 |doi=10.1007/BF00218271 }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal |vauthors=Bepler G, O'briant KC, Kim YC, etal |title=A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region |journal=Genomics |volume=55 |issue= 2 |pages= 164–75 |year= 1999 |pmid= 9933563 |doi= 10.1006/geno.1998.5659 }}
  • {{cite journal |vauthors=Pitterle DM, Kim YC, Jolicoeur EM, etal |title=Lung cancer and the human gene for ribonucleotide reductase subunit M1 (RRM1) |journal=Mamm. Genome |volume=10 |issue= 9 |pages= 916–22 |year= 1999 |pmid= 10441745 |doi=10.1007/s003359901114 }}
  • {{cite journal |vauthors=Guittet O, Håkansson P, Voevodskaya N, etal |title=Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40647–51 |year= 2001 |pmid= 11517226 |doi= 10.1074/jbc.M106088200 |url=http://www.jbc.org/content/276/44/40647.full.pdf }}
  • {{cite journal |vauthors=Kashlan OB, Scott CP, Lear JD, Cooperman BS |title=A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit |journal=Biochemistry |volume=41 |issue= 2 |pages= 462–74 |year= 2002 |pmid= 11781084 |doi=10.1021/bi011653a }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal |vauthors=Kashlan OB, Cooperman BS |title=Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences |journal=Biochemistry |volume=42 |issue= 6 |pages= 1696–706 |year= 2003 |pmid= 12578384 |doi= 10.1021/bi020634d }}
  • {{cite journal |vauthors=Xue L, Zhou B, Liu X, etal |title=Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits |journal=Cancer Res. |volume=63 |issue= 5 |pages= 980–6 |year= 2003 |pmid= 12615712 |doi= }}
  • {{cite journal |vauthors=Gautam A, Li ZR, Bepler G |title=RRM1-induced metastasis suppression through PTEN-regulated pathways |journal=Oncogene |volume=22 |issue= 14 |pages= 2135–42 |year= 2003 |pmid= 12687015 |doi= 10.1038/sj.onc.1206232 }}
  • {{cite journal |vauthors=Rosell R, Scagliotti G, Danenberg KD, etal |title=Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer |journal=Oncogene |volume=22 |issue= 23 |pages= 3548–53 |year= 2003 |pmid= 12789263 |doi= 10.1038/sj.onc.1206419 }}
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