| 词条 | Rs1805054 |
| 释义 |
| rsid = 1805054 | name_1 = C267T | name_2 = 267T/C | gene = HTR6 | chromosome = 1 | alzgene_geneid = 69 | alzgene_polyid = 153 }} In genetics, Rs1805054, also called C267T, is a name used for a specific genetic variation, a single nucleotide polymorphism (SNP), in the HTR6 gene. It is one of the few investigated polymorphisms of its gene. C267T is a synonymous polymorphism. As of 2008 meta-analysis of the polymorphism and Alzheimer's disease indicates that there probably is no association between the two,[1] though individual studies report such an association, e.g., a Chinese study found an association with late-onset Alzheimer's disease.[2] Another reported association in neuropsychiatry disorders is with treatment response in depression.[3] C267T has also been examined in relation to personality traits, with a Korean study finding some evidence for an association with the trait self-transcendence.[4] A Japanese study reported no association with personality traits using the NEO PI-R personality inventory.[5] References1. ^{{Cite web |title = META-ANALYSIS OF ALL PUBLISHED AD ASSOCIATION STUDIES (CASE-CONTROL ONLY) rs1805054 |url = http://www.alzforum.org/res/com/gen/alzgene/meta.asp?geneID=69&polyID=153 |archive-url = https://archive.is/20130225033542/http://www.alzforum.org/res/com/gen/alzgene/meta.asp?geneID=69&polyID=153 |dead-url = yes |archive-date = 2013-02-25 |publisher = Alzheimer Research Forum |accessdate = 2008-07-04}} 2. ^{{Cite journal | author = Rui Kan, Binbin Wang, Chuanfang Zhang, Ze Yang, Shun Ji, Zeping Lu, Chenguang Zheng, Feng Jin & Li Wang | title = Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese | journal = Neuroscience Letters | volume = 372 | issue = 1 | pages = 27–29 |date=November 2004 | doi = 10.1016/j.neulet.2004.09.007 | pmid = 15531082}} 3. ^{{Cite journal | author = Seung-Hwan Lee, Kang-Joon Lee, Heon-Jeong Lee, Byung-Joo Ham, Seung-Ho Ryu & Min-Soo Lee | title = Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder | journal = Psychiatry and Clinical Neurosciences | volume = 59 | issue = 2 | pages = 140–145 |date=April 2005 | doi = 10.1111/j.1440-1819.2005.01348.x | pmid = 15823158}} 4. ^{{Cite journal | author = Byung-Joo Ham, Yong-Ho Kim, Myung-Jin Choi, Ji-Hyun Cha, Yun-Kyeung Choi & Min-Soo Lee | title = Serotonergic genes and personality traits in the Korean population | journal = Neuroscience Letters | volume = 354 | issue = 1 | pages = 2–5 |date=January 2004 | pmid = 14698468 | doi = 10.1016/S0304-3940(03)00753-5}} 5. ^{{Cite journal | author = Mamoru Tochigi, Hiroyuki Hibino, Takeshi Otowa, Toshiyuki Ohtani, Takashi Ebisawa, Nobumasa Kato & Tsukasa Sasaki | title = No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population | journal = Neuroscience Letters | volume = 403 | issue = 1–2 | pages = 100–102 |date=July 2006 | doi = 10.1016/j.neulet.2006.04.020 | pmid = 16682118}} 1 : SNPs on chromosome 1 |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。