| 词条 | Rs6311 |
| 释义 |
| rsid = 6311 | name_1 = -1438G/A | name_2 = -1438A/G | name_3 = A-1438G | name_4 = G-1428A | gene = HTR2A | chromosome = 13 | szgene_geneid = 293 | szgene_polyid = 1871 }} In genetics, rs6311 is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor. 5-HT2A is a neuroreceptor, and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the Temperament and Character Inventory[1][2][3][4] or with a psychological task measuring impulsive behavior.[5] The SNP has also been investigated in rheumatology studies.[6][7] Some research studies may refer to this gene variation as a C/T SNP,[2] while others refer to it as a G/A polymorphism in the promoter region, thus writing it as, e.g., −1438 G/A or 1438G>A.[8][9][10] {{As of|2008}}, meta-analysis of research studies indicates that people with the A-allele may have slightly elevated risk of schizophrenia.[11]rs6313, rs6314, and rs7997012 are other investigated SNPs in the HTR2A gene. References1. ^{{Cite journal |vauthors=Ham BJ, Kim YH, Choi MJ, Cha JH, Choi YK, Lee MS | title = Serotonergic genes and personality traits in the Korean population | journal = Neurosci. Lett. | volume = 354 | issue = 1 | pages = 2–5 |date=January 2004 | pmid = 14698468 | doi = 10.1016/S0304-3940(03)00753-5}} {{genetics-stub}}2. ^1 {{Cite journal |vauthors=Giegling I, Hartmann AM, Möller HJ, Rujescu D | title = Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene | journal = Journal of Affective Disorders | volume = 96 |date=November 2006 | pages = 75–81 | doi = 10.1016/j.jad.2006.05.016 | issue = 1–2 | pmid = 16814396}} 3. ^{{Cite journal |vauthors=Unschuld PG, Ising M, Erhardt A, Lucae S, Kloiber S, Kohli M, Salyakina D, Welt T, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME | title = Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder | journal = Am J Med Genet B | volume = 144B | issue = 4 | pages = 424–429 |date=June 2007 | doi = 10.1002/ajmg.b.30412 | pmid = 17440930}} 4. ^{{Cite journal |vauthors=Serretti A, Calati R, Giegling I, Hartmann AM, Möller HJ, Colombo C, Rujescu D | title = 5-HT2A SNPs and the Temperament and Character Inventory | journal = Progress in Neuro-Psychopharmacology and Biological Psychiatry | volume = 31 | issue = 6 |date=August 2007 | pages = 1275–1281 | doi = 10.1016/j.pnpbp.2007.05.008 | pmid = 17590256}} 5. ^{{Cite journal |vauthors=Nomura M, Kusumi I, Kaneko M, Masui T, Daiguji M, Ueno T, Koyama T, Nomura Y | title = Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior | journal = Psychopharmacology | volume = 187 | issue = 1 | pages = 30–35 |date=July 2006 | doi = 10.1007/s00213-006-0398-z | pmid = 16767413}} 6. ^{{Cite journal |vauthors=Tander B, Gunes S, Boke O, Alayli G, Kara N, Bagci H, Canturk F | title = Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility | journal = Rheumatology International | volume = 28 | issue = 7 |date=May 2008 | pages = 685–691 | doi = 10.1007/s00296-008-0525-8 | pmid = 18196244}} 7. ^{{Cite journal |vauthors=Kling A, Seddighzadeh M, Ärlestig L, Alfredsson L, Rantapää-Dahlqvist S, Padyukov L | title = Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis | journal = Ann. Rheum. Dis. | year = 2007 | doi = 10.1136/ard.2007.074948 | pmid = 18006541 | volume = 67 | pages = 1111–5 | issue = 8}} 8. ^{{Cite journal |vauthors=Reynolds CA, Jansson M, Gatz M, Pedersen NL | title = Longitudinal change in memory performance associated with HTR2A polymorphism | journal = Neurobiology of Aging | volume = 27 | issue = 1 |date=January 2006 | pages = 150–154 | doi = 10.1016/j.neurobiolaging.2004.12.009 | pmid = 16298250}} 9. ^{{Cite journal |vauthors=Halder I, Muldoon MF, Ferrell RE, Manuck SB | title = Serotonin Receptor 2A (HTR2A) Gene Polymorphisms Are Associated with Blood Pressure, Central Adiposity, and the Metabolic Syndrome | journal = Metabolic Syndrome and Related Disorders |date=December 2007 | volume = 5 | issue = 4 | pages = 323–330 | doi = 10.1089/met.2007.0008 | pmid = 18370802 | pmc=3237193}} 10. ^{{Cite journal |vauthors=Saiz PA, Garcia-Portilla MP, Arango C, Morales B, Bascaran MT, Martinez-Barrondo S, Florez G, Sotomayor E, Paredes B, Alvarez C, San Narciso G, Carreño E, Bombin I, Alvarez V, Coto E, Fernandez JM, Bousoño M, Bobes J | title = Association study between obsessive–compulsive disorder and serotonergic candidate genes | journal = Progress in Neuro-Psychopharmacology and Biological Psychiatry | volume = 32 | issue = 3 |date=April 2008 | pages = 765–770 | doi = 10.1016/j.pnpbp.2007.12.005 | pmid = 18191318}} 11. ^{{Cite web | url = http://www.schizophreniaforum.org/res/sczgene/meta.asp?geneID=293 | title = Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs6311 | publisher = Schizophrenia Research Forum | accessdate = 2008-06-10}} 1 : SNPs on chromosome 13 |
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