| 词条 | R-spondin 2 |
| 释义 |
R-spondin 2 synergizes with Wnt to activate beta-catenin.[2][3] RSPO2 has been proposed to regulate craniofacial patterning and morphogenesis within pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway.[4] In dogs, the Rspo2 gene determines hair growth.[5] References1. ^{{cite web | title = Entrez Gene: R-spondin 2 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=340419 }} {{NLM content}}{{gene-8-stub}}2. ^{{cite journal | vauthors = Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD | title = R-Spondin proteins: a novel link to beta-catenin activation | journal = Cell Cycle | volume = 5 | issue = 1 | pages = 23–6 |date=January 2006 | pmid = 16357527 | doi = 10.4161/cc.5.1.2305| url = }} 3. ^{{cite journal | vauthors = Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W | title = R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis | journal = Dev. Cell | volume = 7 | issue = 4 | pages = 525–34 |date=October 2004 | pmid = 15469841 | doi = 10.1016/j.devcel.2004.07.019 | url = }} 4. ^{{Cite journal | vauthors = Jin YR, Turcotte TJ, Crocker AL, Han XH, Yoon JK| title = The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal–mesenchymal interaction | doi = 10.1016/j.ydbio.2011.01.004 | journal = Developmental Biology | volume = 352 | issue = 1 | pages = 1–13 | year = 2011 | pmid = 21237142 | pmc =3089906 }} 5. ^{{cite journal | vauthors = Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA | title = Coat variation in the domestic dog is governed by variants in three genes | journal = Science | volume = 326 | issue = 5949 | pages = 150–3 |date=October 2009 | pmid = 19713490 | pmc = 2897713 | doi = 10.1126/science.1177808 }} 2 : Glycoproteins|Extracellular matrix proteins |
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