| 词条 | RU-24,969 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 449586484 | IUPAC_name = 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole | image = RU-24969_structure.png | width = 200 | tradename = | legal_status = | IUPHAR_ligand = 23 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 107008-28-6 | PubChem = 108029 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 97138 | C=14 | H=16 | N=2 | O=1 | molecular_weight = 228.289 g/mol | smiles = c3cc(OC)cc1c3[nH]cc1C=2CCNCC=2 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = KRVMLPUDAOWOGN-UHFFFAOYSA-N }}RU-24,969 is a drug and research chemical widely used in scientific studies. It is a selective agonist at the 5-HT1A and 5-HT1B receptors, with preference for the latter.[1] As with other 5-HT1B agonists such as CP-94,253, RU-24,969 has been found to increase the reinforcing properties of cocaine, suggesting a role for 5-HT1B receptors in cocaine addiction.[2] See also
References1. ^{{cite journal | vauthors = Doods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, Van Zwieten PA | title = Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity. | journal = Eur J Pharmacol | volume = 112 | issue = 3 | pages = 363–370 | year = 1985 | pmid = 3160596 | doi = 10.1016/0014-2999(85)90782-4 }} {{Serotonergics}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Parsons LH, Weiss F, Koob GF |title=Serotonin1B receptor stimulation enhances cocaine reinforcement |journal=Journal of Neuroscience |volume=18 |issue=23 |pages=10078–89 |date=December 1998 |pmid=9822762 |doi= |url=}} 2 : Serotonin receptor agonists|Phenol ethers |
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