| 释义 |
- References
- Further reading
{{Infobox_gene}}S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.[2]
}}References1. ^{{cite journal | vauthors = Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW | title = Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 14 | pages = 6547–51 |date=Aug 1993 | pmid = 8341667 | pmc = 46969 | doi =10.1073/pnas.90.14.6547 }}
2. ^1 {{cite web | title = Entrez Gene: S100A3 S100 calcium binding protein A3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6274| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134–40 |year= 1996 |pmid= 8701470 |doi= 10.1016/S0968-0004(96)80167-8}}
- {{cite journal |vauthors=Föhr UG, Heizmann CW, Engelkamp D, etal |title=Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc. |journal=J. Biol. Chem. |volume=270 |issue= 36 |pages= 21056–61 |year= 1995 |pmid= 7673133 |doi=10.1074/jbc.270.36.21056 }}
- {{cite journal |vauthors=Schäfer BW, Wicki R, Engelkamp D, etal |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=10.1016/0888-7543(95)80005-7 }}
- {{cite journal | vauthors=Kizawa K, Uchiwa H, Murakami U |title=Highly-expressed S100A3, a calcium-binding protein, in human hair cuticle. |journal=Biochim. Biophys. Acta |volume=1312 |issue= 2 |pages= 94–8 |year= 1996 |pmid= 8672544 |doi=10.1016/0167-4889(96)00023-7 }}
- {{cite journal |vauthors=Böni R, Burg G, Doguoglu A, etal |title=Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions. |journal=Br. J. Dermatol. |volume=137 |issue= 1 |pages= 39–43 |year= 1997 |pmid= 9274623 |doi=10.1111/j.1365-2133.1997.tb03698.x }}
- {{cite journal | vauthors=Groves P, Finn BE, Kuźnicki J, Forsén S |title=A model for target protein binding to calcium-activated S100 dimers. |journal=FEBS Lett. |volume=421 |issue= 3 |pages= 175–9 |year= 1998 |pmid= 9468301 |doi=10.1016/S0014-5793(97)01535-4 }}
- {{cite journal |vauthors=Ridinger K, Ilg EC, Niggli FK, etal |title=Clustered organization of S100 genes in human and mouse. |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 254–63 |year= 1999 |pmid= 9920416 |doi= 10.1016/S0167-4889(98)00137-2}}
- {{cite journal | vauthors=Fritz G, Heizmann CW, Kroneck PM |title=Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model. |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 264–76 |year= 1999 |pmid= 9920417 |doi= 10.1016/S0167-4889(98)00138-4}}
- {{cite journal |vauthors=Hoyaux D, Decaestecker C, Heizmann CW, etal |title=S100 proteins in Corpora amylacea from normal human brain. |journal=Brain Res. |volume=867 |issue= 1–2 |pages= 280–8 |year= 2000 |pmid= 10837826 |doi=10.1016/S0006-8993(00)02393-3 }}
- {{cite journal |vauthors=Fritz G, Mittl PR, Vasak M, etal |title=The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33092–8 |year= 2002 |pmid= 12045193 |doi= 10.1074/jbc.M200574200 }}
- {{cite journal |vauthors=Mittl PR, Fritz G, Sargent DF, etal |title=Metal-free MIRAS phasing: structure of apo-S100A3 |journal=Acta Crystallogr. D |volume=58 |issue= Pt 8 |pages= 1255–61 |year= 2003 |pmid= 12136135 |doi=10.1107/S0907444902008430 }}
- {{cite journal |vauthors=Kizawa K, Troxler H, Kleinert P, etal |title=Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 857–62 |year= 2003 |pmid= 12470658 |doi=10.1016/S0006-291X(02)02744-4 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
- {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
- {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
{{refend}}{{PDB Gallery|geneid=6274}}{{gene-1-stub}} 1 : S100 proteins |