| 词条 | S-15535 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 405474334 | IUPAC_name = 1-(2,3-dihydro-1,4-benzodioxin-8-yl)-4-(2,3-dihydro-1H-inden-2-yl)piperazine | image = S-15535_structure.png | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 146998-34-7 | ATC_prefix = none | ATC_suffix = | PubChem = 132787 | IUPHAR_ligand = 26 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 49247 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 117196 | C=21 | H=24 | N=2 | O=2 | molecular_weight = 336.427 g/mol | smiles = C1CN(CCN1C2CC3=CC=CC=C3C2)C4=C5C(=CC=C4)OCCO5 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = QJPPEMXOOWNICQ-UHFFFAOYSA-N }}S-15535 is a phenylpiperazine drug which is a potent and highly selective 5-HT1A receptor ligand that acts as an agonist and antagonist (weak partial agonist) at the presynaptic and postsynaptic 5-HT1A receptors, respectively.[1][2][3][4] It has anxiolytic properties.[4][5] See also
References1. ^{{cite journal | vauthors = Millan MJ, Rivet JM, Canton H, Lejeune F, Gobert A, Widdowson P, Bervoets K, Brocco M, Peglion JL | title = S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist (weak partial agonist) at presynaptic and postsynaptic sites respectively | journal = Eur J Pharmacol | volume = 230 | issue = 1 | pages = 99–102 | year = 1993 | pmid = 8381359 | doi = 10.1016/0014-2999(93)90416-F }} {{Anxiolytics}}{{Serotonergics}}{{Piperazines}}2. ^{{cite journal |vauthors=Millan MJ, Canton H, Gobert A, Lejeune F, Rivet JM, Bervoets K, Brocco M, Widdowson P, Mennini T, Audinot V, etal | title = Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists | journal = J Pharmacol Exp Ther | volume = 268 | issue = 1 | pages = 337–352 | year = 1994 | pmid = 8301575 }} 3. ^{{cite journal | vauthors = Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A | title = S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity | journal = J Pharmacol Exp Ther | volume = 282 | issue = 1 | pages = 132–147 | year = 1997 | pmid = 9223549 }} 4. ^1 {{cite journal | vauthors = Lejeune F, Millan MJ | title = Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535 | journal = Synapse | volume = 30 | issue = 2 | pages = 172–180 | year = 1998 | pmid = 9723787 | doi = 10.1002/(SICI)1098-2396(199810)30:2<172::AID-SYN7>3.0.CO;2-9 }} 5. ^{{cite journal | doi = 10.1007/s002130000449 | vauthors = Dekeyne A, Brocco M, Adhumeau A, Gobert A, Millan MJ | title = The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents | journal = Psychopharmacology | volume = 152 | issue = 1 | pages = 55–66 | year = 2000 | pmid = 11041316 }} 3 : Piperazines|Indanes|Benzodioxans |
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