“(S)-3-amino-2-methylpropionate transaminase”的意思、由来-开放百科全书

词条

(S)-3-amino-2-methylpropionate transaminase

释义

References

{{enzyme
| Name = (S)-3-amino-2-methylpropionate transaminase
| EC_number = 2.6.1.22
| CAS_number = 9031-95-2
| IUBMB_EC_number = 2/6/1/22
| GO_code = 0047298
| image =
| width =
| caption =
}}

In enzymology, a (S)-3-amino-2-methylpropionate transaminase ({{EC number|2.6.1.22}}) is an enzyme that catalyzes the chemical reaction

(S)-3-amino-2-methylpropanoate + 2-oxoglutarate 2-methyl-3-oxopropanoate + L-glutamate

Thus, the two substrates of this enzyme are (S)-3-amino-2-methylpropanoate and 2-oxoglutarate, whereas its two products are 2-methyl-3-oxopropanoate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is (S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase. Other names in common use include L-3-aminoisobutyrate transaminase, beta-aminobutyric transaminase, L-3-aminoisobutyric aminotransferase, and beta-aminoisobutyrate-alpha-ketoglutarate transaminase. This enzyme participates in valine, leucine and isoleucine degradation.

References

{{cite journal |vauthors=Kakimoto Y, Kanazawa A, Taniguchi K, Sano I | date = 1968 | title = Beta-aminoisobutyrate-alpha-ketoglutarate transaminase in relation to beta-aminoisobutyric aciduria | journal = Biochim. Biophys. Acta | volume = 156 | pages = 374–80 | pmid = 5641913 | issue = 2 | doi=10.1016/0304-4165(68)90267-5}}
{{cite journal |vauthors=Tamaki N, Sakata SF, Matsuda K | date = 2000 | title = Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver | journal = Methods Enzymol. | volume = 324 | pages = 376–89 | pmid = 10989446 | doi = 10.1016/S0076-6879(00)24247-X | series = Methods in Enzymology | isbn = 978-0-12-182225-5 }}

2 : EC 2.6.1|Enzymes of unknown structure

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