S49 may refer to :

• Keep only in the original container, a safety phrase in chemistry
• S49 postcode for Chesterfield bulk users
• County Route S49, a county route in Bergen County, New Jersey
• Ikarus S-49, a 1946 Yugoslav fighter aircraft
• USS S-49 (SS-160), a 1921 S-class submarine of the United States Navy
• Vale, Oregon's Miller Memorial Airpark FAA LID

• Political ReviewNet
• Political riots
• Political satires
• Political satirist
• Political scandals during the Carter administration
• Political scandals during the Clinton Administration
• Political scandals during the Eisenhower administration
• Political scandals during the Ford administration
• Political scandals during the George H. W. Bush Administration
• Political scandals during the George W. Bush Administration
• Political scandals during the Grant administration
• Political scandals during the Harding administration
• Political scandals during the Kennedy administration
• Political scandals during the Lyndon B. Johnson Administration
• Political scandals during the Nixon administration
• Political scandals during the Obama administration
• Political scandals during the Reagan administration
• Political scandals during the Truman administration
• Political scandals in Logan County, West Virginia
• Political scandals of Australia
• Political scandals of Belgium
• Political scandals of Colombia
• Political scandals of Germany
• Political scandals of India
• Political scandals of Ireland