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词条 Saccharolipid
释义

  1. See also

  2. References

Saccharolipids describe compounds in which fatty acids are linked directly to a sugar backbone, forming structures that are compatible with membrane bilayers. In the saccharolipids, a monosaccharide substitutes for the glycerol backbone present in glycerolipids and glycerophospholipids. The most familiar saccharolipids are the acylated glucosamine precursors of the lipid A component of the lipopolysaccharides in Gram-negative bacteria. Typical lipid A molecules are disaccharides of glucosamine, which are derivatized with as many as seven fatty-acyl chains. The minimal lipopolysaccharide required for growth in E. coli is Kdo2-Lipid A, a hexa-acylated disaccharide of glucosamine that is glycosylated with two 3-deoxy-D-manno-octulosonic acid (Kdo) residues.[2]

See also

  • Lipids

References

1. ^{{cite journal |author1=Raetz, Christian R. H. |author2=Guan, Ziqiang |author3=Ingram, Brian O. |author4=Six, David A. |author5=Song, Feng |author6=Wang, Xiaoyuan |author7=Zhao, Jinshi | title = Discovery of new biosynthetic pathways: the lipid A story | journal = Journal of Lipid Research | year = 2009 | pages = S103–S108}}
2. ^{{cite journal |author1=Raetz CR |author2=Garrett TA |author3=Reynolds CM |author4=Shaw WA |author5=Moore JD |author6=Smith DC Jr |author7=Ribeiro AA |author8=Murphy RC |author9=Ulevitch RJ |author10=Fearns C |author11=Reichart D |author12=Glass CK |author13=Benner C |author14=Subramaniam S |author15=Harkewicz R |author16=Bowers-Gentry RC |author17=Buczynski MW |author18=Cooper JA |author19=Deems RA |author20=Dennis EA | year = 2006 | title = Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4 | journal = Journal of Lipid Research | volume = 47 | pages = 1097–1111 | doi = 10.1194/jlr.M600027-JLR200 | pmid = 16479018 | issue = 5}}

1 : Lipids
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